antimycin a2

Antimycin A2 is a principal constituent and the biologically active component of the antibiotic complex known as Antimycin A, which exerts its inhibitory activity against a range of fungal species and certain insects through a primary mechanism of action involving the potent inhibition of cellular respiration by blocking the reoxidation of cytochrome b within the mitochondrial electron transport chain.

Anticancer Agent 141 (Compound AE), an antimycin alkaloid, exhibits inhibitory potential against HPV-infected cervical cancer. It impedes HeLa cell proliferation by arresting the cell cycle at the S phase and induces caspase-dependent apoptosis through mitochondrial disruption. This disruption activates the ROS-mediated ubiquitin-dependent proteasome system, leading to the degradation of E6/E7 oncoproteins [1].