androstenedione

11-Beta-hydroxyandrostenedione (NSC-17102) is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue), which is a 11β-hydroxysteroid dehydrogenase isozymes inhibitor. Measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism with 4-androstenedione increases.

Exemestane (EXE) is an Aromatase Inhibitor. The mechanism of action of exemestane is as an Aromatase Inhibitor.

Androstenedione-D7 is a deuterated compound of the steroid hormone Androstenedione (T7990), and is used to study the metabolism of Androstenedione.

Androstenedione-D7 (Standard) is a reference standard of Androstenedione-D7 intended for quantitative analysis, quality control, and related biochemical research applications. Androstenedione-d7 is a deuterated compound of the steroid hormone Androstenedione, and is used to study the metabolism of Androstenedione.

11-Beta-hydroxyandrostenedione (Standard) is a reference standard for research and analysis in studies involving 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (NSC-17102) is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue), which is a 11β-hydroxysteroid dehydrogenase isozymes inhibitor. Measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism with 4-androstenedione increases.

11-Ketoandrostenedione-[2.3.4-13C3] (Standard) is a reference standard of 11-Ketoandrostenedione-[2.3.4-13C3] intended for quantitative analysis, quality control, and related biochemical research applications.

11-Ketoandrostenedione-[3,4-13C2, 1-D] (Standard) is a reference standard of 11-Ketoandrostenedione-[3,4-13C2, 1-D] intended for quantitative analysis, quality control, and related biochemical research applications.

11-Hydroxyandrostenedione-[9,11,12,12-D4] (Standard) is a reference standard of 11-Hydroxyandrostenedione-[9,11,12,12-D4] intended for quantitative analysis, quality control, and related biochemical research applications.

Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex.

Estrone (Aquacrine) is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.

LX1, an anti-prostate cancer compound, specifically targets the androgen receptor (AR), AR variants, and the steroidogenic enzyme AKR1C3. It inhibits AKR1C3's enzymatic function, decreases the conversion of androstenedione to testosterone, and reduces the expression of both AR and AR-V7, subsequently downregulating their target genes. Additionally, LX1 is effective in overcoming tumor cell resistance to Enzalutamide, and when combined with Enzalutamide, it further suppresses tumor growth.

11β-HSD2-IN-1 (compound CDSN) serves as a potent inhibitor of 11β-HSD2, effectively hindering this enzyme from metabolizing Cholestane-3β,5α,6β-triol (CT) into carcinogenic androstenedione within cells. By inhibiting testosterone biosynthesis, 11β-HSD2-IN-1 suppresses the proliferation of MCF-7 cells. Additionally, this compound exhibits immunological activity and offers protection against viral infections.

Aromatase-IN-3 (compound 7d) is an aromatase inhibitor with an IC50 of 54 nM. It effectively suppresses the conversion of androstenedione to estrogen catalyzed by aromatase, demonstrating significant tumor growth inhibition in breast cancer cell lines, suggesting its potential application in ER+ cancer research.

16α-Hydroxyetiocholanolone is a metabolite of 16α-hydroxydehydroisoandrosterone (16α-DHEA) and androstenedione.1,2 1.Lai, E.Y., and Solomon, S.The in vivo metabolism of 16ɑ-hydroxydehydroisoandrosterone in manBiochemistry6(7)2040-2052(1967) 2.Christakoudi, S., Cowan, D.A., Christakudis, G., et al.21-hydroxylase deficiency in the neonate - trends in steroid anabolism and catabolism during the first weeks of lifeJ. Steroid Biochem. Mol. Biol.138334-347(2013)

4-Androsten-11β-ol-3,17-dione-D7 is a deuterated compound of 4-Androsten-11β-ol-3,17-dione. 4-Androsten-11β-ol-3,17-dione (T14001) has a CAS number of 382-44-5. 11-Beta-hydroxyandrostenedione is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue), which is a 11β-hydroxysteroid dehydrogenase isozymes inhibitor. Measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism with 4-androstenedione increases.

Estrone-D4 is a deuterated compound of Estrone. Estrone (T1009) has a CAS number of 53-16-7. Estrone (T1009) is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.

Estrone-D2 is a deuterated compound of Estrone. Estrone (T1009) has a CAS number of 53-16-7. Estrone (T1009) is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.

4-Androstene-3,17-dione-13C3 is the 13C labeled compound of 4-Androstene-3,17-dione. 4-Androstene-3,17-dione has a CAS number of 63-05-8. Androstenedione is a delta-4 19-carbon steroid that is produced in the testis

Estrone (Standard) is the standard substance of Estrone, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Estrone (Aquacrine) is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.

4-Androstene-3,17-Dione-13C3 (Standard) is a reference standard of 4-Androstene-3,17-Dione-13C3 intended for quantitative analysis, quality control, and related biochemical research applications. 4-Androstene-3,17-dione-13C3 is the 13C labeled compound of 4-Androstene-3,17-dione. 4-Androstene-3,17-dione has a CAS number of 63-05-8. Androstenedione is a delta-4 19-carbon steroid that is produced in the testis

Estrone-D2 (Standard) is a reference standard of Estrone-D2 intended for quantitative analysis, quality control, and related biochemical research applications. Estrone-d2 is a deuterated compound of Estrone. Estrone has a CAS number of 53-16-7. Estrone is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.

Estrone-D4 (Standard) is a reference standard of Estrone-D4 intended for quantitative analysis, quality control, and related biochemical research applications. Estrone-d4 is a deuterated compound of Estrone. Estrone has a CAS number of 53-16-7. Estrone is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.