T8876

PF-06882961 Tris (UNII-2HJV78O0SS) is an orally bioavailable glucagon-like peptide-1 receptor (GLP-1R) agonist.

PBA-1105b, a longer PEGylated derivative of PBA-1105, is an autophagy-targeting chimeric compound (AUTOTAC) that can induce self-oligomerization of p62. It enhances the autophagic flux of Ub-bound aggregates.

ITI-333 is a tetracyclic compound with oral activity and analgesic properties, targeting multiple receptors. This compound is utilized in research across various forms of pain.

Sp-8-Cl-cAMPS, as a derivative and analogue of cAMP, can inhibit the growth of various human tumor cells, such as leukemia cells HL-60 and colon cancer cells LS-174T, with an IC50 range of 8-100 μM. In addition, this compound can activate protein kinase cAKI and cAKII, with Ka values of 0.25 μM and 3.2 μM, respectively.

PDHK-IN-7 (compound 32) acts as an inhibitor of pyruvate dehydrogenase kinase, exhibiting an IC50 value of 17 nM. Additionally, it activates PDH in rat liver and demonstrates a glucose-lowering effect in Zucker obese rats.