T8262

Fosfomycin sodium is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an early stage in cell wall synthesis.

D359-0396, an orally active NLRP3 inflammasome inhibitor, mitigates pyroptosis and reduces IL-1β release in macrophages by inhibiting the oligomerization of NLRP3, ASC, and the cleavage of GSDMD. The compound is effective in alleviating Experimental Autoimmune Encephalomyelitis (EAE) and enhances survival following septic shock in mice [1].

D1N8 is a potent inhibitor of the SARS-CoV-2 3CL protease, displaying an IC50 value of 0.44 μM and a CC50 value of greater than 20 μM. It holds promise for the development of anti-SARS-CoV-2 agents that target the 3CL protease [1].

D1N52 is a potent inhibitor of the SARS-CoV-2 3CL protease, demonstrating an inhibitory concentration half-maximal (IC50) value of 0.53 μM [1].

D-{Ala-Ala-Ala-Ala-Ala}, a pentapeptide, acts as an inhibitor of immunological responses [1].

Cytochalasin O (compound 13), a secondary metabolite produced by the phytopathogenic fungus P. sp. CIB-109 [1], is characterized by its bioactive properties.