T6211

Posaconazole (POS) is a sterol C14ɑ demethylase inhibitor (IC50: 0.25 nM).

MK2-IN-4, a MAPKAPK2 (MK2) inhibitor with an IC50 of 45 nM, can be used in cancer, inflammation, and immunology studies.

Antioxidant agent-5 (compound D-6) is a potent antioxidant that inhibits oxLDL-induced increases in ROS levels and NF-κB nuclear translocation. It also prevents oxLDL (oxidized LDL)-induced apoptosis (VECs), activates the Nrf2/HO-1 antioxidant pathway, and exhibits protective activity against oxLDL-induced endothelial damage.

CDK8-IN-6 (compound 9) is a potent inhibitor of cyclin-dependent kinase 8 (CDK8) with a Kd of 13 nM, demonstrating significant research potential in AML cancers.

EGFR-IN-49 is a potent and selective EGFR inhibitor that targets EGFRT790M (IC50: 65.0 nM) and EGFRT790M/L858R (IC50: 13.6 nM), inducing apoptosis in a dose-dependent manner.

JAK3-IN-12 (compound 15k) is a potent inhibitor of JAK3 (IC50: 9.5 nM) and can be used in the study of rheumatoid arthritis.

HBV-IN-24 (compound (2 S, 6S)-1a) is a potent inhibitor of HBV. HBV-IN-24 is a strong inhibitor of HBV DNA (EC50: 0.6 nM), HBsAg (EC50: 0.6 nM) and HBeAg (EC50: 4.6 nM). antiviral effect and was able to improve neurotoxicity.

ALK5-IN-33 (Compound EX-10) is an orally active and selective inhibitor of ALK-5 with an IC50 ≤ 10 nM.

ALK5-IN-34 is a selective, orally active inhibitor of activin receptor-like kinase (ALK), which inhibits the activity of activin receptor-like kinase (IC50 ≤ 10 nM) and also inhibits tumour growth.

KIF18A-IN-4 is a moderately potent, non-competitive KIF18A inhibitor of ATP and microtubule with an IC50 of 6.16 μM. It selectively acts on many mitotic kinesins and kinases, without directly affecting microtubule protein assembly, and shows anti-tumour effects.

Lasofoxifene (CP-336156) is a selective oestrogen receptor modulator/antagonist that reduces serum IL-6 levels and inhibits joint inflammation and osteoporosis. It suppresses primary tumour growth and metastasis, making it suitable for breast cancer research.