T1754

ZM 306416 (CB 676475), a VEGFR1 inhibitor (IC50: 0.33 μM), can also inhibit EGFR (IC50<10 nM).

Biotin-C5-amino-C5-amino is an alkyl chain-based PROTAC linker utilized in PROTAC synthesis.

BCN-SS-NHS, a cleavable linker essential in ADC synthesis, joins cytotoxic drugs to antibodies, enabling precise delivery to target cells or proteins. Its cleavable nature ensures controlled drug release, optimizing the effectiveness of ADCs.

Benzaldehyde-PEG4-azide is a polyethylene glycol (PEG) derivative utilized as a linker for the construction of proteolysis targeting chimeras (PROTACs)[1].

Benzyl-N-bis(PEG3-Boc) is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands necessary for PROTAC formation, thereby enabling selective protein degradation via the ubiquitin-proteasome system within cells.

BI-3663 is a highly selective PTK2/FAK PROTAC that utilizes cereblon ligands to hijack E3 ligases for PTK2 degradation, with an IC50 of 18 nM. It is composed of BI-4464 linked to Pomalidomide with a linker[1]. Anti-cancer.

Biotin-amido-PEG4-PFP ester is a Polyethylene glycol (PEG)-based PROTAC linker used in the synthesis of PROTACs [1].

Biotin-BS is a chemical compound composed of two distinct ligands: methyl-bestatin (MeBS) for cIAP1 and biotin. These ligands are interconnected through linkers. MeBS serves as a ligand specifically for the cellular inhibitor of apoptosis protein 1 (cIAP1) ubiquitin ligase[1].

Biotin-C1-PEG3-C3-amine (TFA) is a polyethylene glycol (PEG) linker essential for the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Biotin-C10-NHS Ester, an alkyl/ether-based linker compound, is utilized in the synthesis of PROTACs[1].

Biotin-EDA, an alkyl chain-based PROTAC linker, is utilized in PROTAC synthesis.