T1011

Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes necessary for ERGOSTEROL synthesis.

SB-T-101141 is a novel taxane drug effective in inducing atypical ferroptosis, thereby overcoming resistance of breast cancer to Paclitaxel. It promotes the generation of iron ions, ferrous ions, and reactive oxygen species (ROS). SB-T-101141 stably binds to KHSRP, inhibiting the expression of the iron-dependent CISD1 related to iron homeostasis. It synergistically enhances the activation of the iron-dependent JNK and PERK pathways through KHSRP. SB-T-101141 inhibits breast tumor growth in MCF-7(PR)/MDA-MB-231(PR) or KHSRP knockout MCF-7 xenograft mouse models.