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Search Results for " mdr1 "

Targets

35

Compounds

20

Natural Products

3

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T8426 Encequidar HM30181,HM30181A P-gp
Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.
T12341 P-gp inhibitor 1 Others , P-gp
P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).
T16561 Polyoxyethylene stearate POES Antibacterial , P-gp
Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.
T11071 Dofequidar fumarate MS-209 P-gp
Dofequidar fumarate (MS-209)(MS-209 fumarate), an orally active quinoline compound, has been reported to overcome MDR by inhibiting ABCB1/P-gp, ABCC1/MDR-associated protein 1.
T6287 Tariquidar XR9576 P-gp
Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.
T0351 Risperidone Risperidal,R 64 766 Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , P-gp
Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
T4059 Selamectin UK-124114 Chloride channel , P-gp , Parasite
Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. In an H. contortus larval development assay, sel...
T13383 Zamicastat BIA 5-1058 BCRP , Hydroxylase , P-gp
Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0 μM, respectively).
T8389 Trifluoperazine trifluoroperazine CaMK , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , P-gp , Autophagy
Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.
T11578L Encequidar mesylate HM30181 mesylate,HM30181A mesylate P-gp
Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.
T0100L Atazanavir Zrivada,Reyataz,Latazanavir,BMS-232632 P450 , SARS-CoV , HIV Protease , P-gp
Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.
T1634 Glibenclamide Glyburide Potassium Channel , Mitochondrial Metabolism , CFTR , P-gp , Autophagy
Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T20656 Verapamil NSC 135784,NSC-135784,CP-16533-1,(±)-Verapamil P450 , Calcium Channel , P-gp
Verapamil (CP-16533-1) is a calcium channel blocker and an orally active and effective inhibitor of P-gp. Verapamil inhibits CYP3A4 and can be used in studies about the treatment of high blood pressure, heart arrhythmias...
T16339 Norverapamil hydrochloride (±)-Norverapamil hydrochloride,D591 hydrochloride Calcium Channel , P-gp , Drug Metabolite
Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.
T1010 Verapamil hydrochloride Manidon,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride P450 , Calcium Channel , P-gp
Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.
T0100 Atazanavir sulfate BMS-232632,BMS-232632 sulfate P450 , SARS-CoV , HIV Protease , P-gp
Atazanavir sulfate (BMS-232632 sulfate) is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS.
T1222 Trifluoperazine dihydrochloride Trifluoperazine 2HCl,SKF5019,Urinox CaMK , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , P-gp , Autophagy
Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.
T2657 Elacridar GW0918,GW120918,GF120918,GG918 BCRP , P-gp
Elacridar (GG918) (GF120918) is an effective BCRP and P-gp (MDR-1) inhibitor.
T6018 Zosuquidar trihydrochloride Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride P-gp
Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.
T67821 GS-9191 PM BCRP , Antiviral
GS-9191 PM is a novel antitumorviral compound, a bis-amide prodrug of the nucleotide analog 9-(2-phosphonomethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine (cPrPMEDAP).GS-9191 PM is a potent inhibitor of MDR1 and BCRP.GS-91...
T4595 YHO-13177 YHO 13177,YHO13177 BCRP
YHO-13177 is a potent and specific inhibitor of BCRP; potentiated the cytotoxicity of SN-38 in cancer cells and no effect on P-glycoprotein–mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells.
T22680 CP-100356 hydrochloride CP-100356 HCl,CP 100356 hydrochloride BCRP
CP-100356 hydrochloride is an orally active and low micromolar dual inhibitor of MDR1 (P-gp) and BCRP, a nucleotide-derived substrate analogue with inhibitory effects on MDR1-mediated Calcein-AM transporter and BCRP-medi...
T31069 CP-615003 CP 615003
CP-615003 is a Mdr1 P-glycoprotein substrate.
T71279 BPR1K653
BPR1K653 is a potent Aurora kinase inhibitor with potential anticancder activity. BPR1K653 specifically inhibited the activity of Aurora-A and Aurora-B kinase at low nano-molar concentrations in vitro. BPR1K653 was poten...
T69897 MC-70 hydrochloride
MC-70 hydrochloride is a potent P-gp inhibitor with good selectivity towards BCRP pump (EC50 values 0.05 μM, 0.69 μM, 9.3 μM, and 73 μM for Caco-2, MDR1, MRP1, and BCRP inhibition, respectively).
T70695 CP 100356
CP 100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. The compound has low uM to nM potency for inhibiting several MDR-1 substrates (calcein-AM, digoxin) in transfected MDCKII cells.
T72921 Reversin 121
Reversin 121 is a P-glycoprotein inhibitor. Reversin 121 increases the ATPase activity of MDR1. Reversin 121 reverses P-glycoprotein-mediated multidrug resistance. Reversin 121 can be used in the research of cancers .
T13222 TTT-28 Others
TTT-28 is a thiazole-valine peptidomimetic, and is a selective ABCB1 (P-gp/MDR1) inhibitor with high efficacy and low toxicity, which reverses the ATP-binding cassette sub-family B member 1 (ABCB1)-mediated Multidrug res...
T28901 T-2007 5,5-Diphenylbarbituric acid,DPB
T-2007 is an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist and gamma-aminobutyric acid (GABA) receptor agonist. T2007 and its analogs upregulates CYP3A4 and MDR1. T-2007 depressed both t...
T4047L Bisantrene HCl CL216942,CL-216942,NSC-337766,CL 216942
Bisantrene (CL-216942; NSC 337766) is a topoisomerase II poison and DNA intercalator. It can be used as a Rac1 inhibitor or model compound to study P-glycoprotein-mediated multi-drug resistance (MDR1). Bisantrene inserts...
T79353 P-gp/BCRP-IN-2
P-gp/BCRP-IN-2 (compound 15), an oxadiazole derivative, functions as a dual inhibitor targeting both the ABC transporter P-glycoprotein (IC50: 1.6 nM) and BCRP (IC50: 600 nM). Additionally, it bolsters the anti-prolifera...
T68568 Encequidar, HCl
Encequidar, also known as HM-30181, is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. Encequidar showed the highest potency (IC(50)=0.63nM) among several MD...
T68656 Brivudine monophosphate
Brivudine monophosphate is a phosphate ester of Brivudine. Brivudine, also known as bromovinyl-deoxyuridine, is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. In vitro, bro...
T36807 Estradiol 17-(β-D-Glucuronide) (sodium salt hydrate)
Estradiol 17-(β-D-glucuronide) (E217G) is an estrogen metabolite formed in the liver and subsequently excreted in bile.1It acts as a substrate of the multidrug resistance protein 2 (MRP2; Km= 75 μM), and through MRP2-med...
T36847 Coelenterazine hcp
Coelenterazine hcp is a synthetic bioluminescent luciferin that displays an emission maximum of 445 nm.1It has been used as a calcium indicator and substrate to quantifyRenillaluciferase activity.1,2,3 1.Sabnis, R.W.Hand...

Compounds

Encequidar
T8426
Synonym: HM30181,HM30181A
Target: P-gp
P-gp inhibitor 1
T12341
Synonym:
Target: Others, P-gp
Polyoxyethylene stearate
T16561
Synonym: POES
Target: Antibacterial, P-gp
Dofequidar fumarate
T11071
Synonym: MS-209
Target: P-gp
Tariquidar
T6287
Synonym: XR9576
Target: P-gp
Risperidone
T0351
Synonym: Risperidal,R 64 766
Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, P-gp
Selamectin
T4059
Synonym: UK-124114
Target: Chloride channel, P-gp, Parasite
Zamicastat
T13383
Synonym: BIA 5-1058
Target: BCRP, Hydroxylase, P-gp
Trifluoperazine
T8389
Synonym: trifluoroperazine
Target: CaMK, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, P-gp, Autophagy
Encequidar mesylate
T11578L
Synonym: HM30181 mesylate,HM30181A mesylate
Target: P-gp
Atazanavir
T0100L
Synonym: Zrivada,Reyataz,Latazanavir,BMS-232632
Target: P450, SARS-CoV, HIV Protease, P-gp
Glibenclamide
T1634
Synonym: Glyburide
Target: Potassium Channel, Mitochondrial Metabolism, CFTR, P-gp, Autophagy
Verapamil
T20656
Synonym: NSC 135784,NSC-135784,CP-16533-1,(±)-Verapamil
Target: P450, Calcium Channel, P-gp
Norverapamil hydrochloride
T16339
Synonym: (±)-Norverapamil hydrochloride,D591 hydrochloride
Target: Calcium Channel, P-gp, Drug Metabolite
Verapamil hydrochloride
T1010
Synonym: Manidon,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride
Target: P450, Calcium Channel, P-gp
Atazanavir sulfate
T0100
Synonym: BMS-232632,BMS-232632 sulfate
Target: P450, SARS-CoV, HIV Protease, P-gp
Trifluoperazine dihydrochloride
T1222
Synonym: Trifluoperazine 2HCl,SKF5019,Urinox
Target: CaMK, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, P-gp, Autophagy
Elacridar
T2657
Synonym: GW0918,GW120918,GF120918,GG918
Target: BCRP, P-gp
Zosuquidar trihydrochloride
T6018
Synonym: Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride
Target: P-gp
GS-9191 PM
T67821
Synonym:
Target: BCRP, Antiviral
YHO-13177
T4595
Synonym: YHO 13177,YHO13177
Target: BCRP
CP-100356 hydrochloride
T22680
Synonym: CP-100356 HCl,CP 100356 hydrochloride
Target: BCRP
CP-615003
T31069
Synonym: CP 615003
Target:
BPR1K653
T71279
Synonym:
Target:
MC-70 hydrochloride
T69897
Synonym:
Target:
CP 100356
T70695
Synonym:
Target:
Reversin 121
T72921
Synonym:
Target:
TTT-28
T13222
Synonym:
Target: Others
T-2007
T28901
Synonym: 5,5-Diphenylbarbituric acid,DPB
Target:
Bisantrene HCl
T4047L
Synonym: CL216942,CL-216942,NSC-337766,CL 216942
Target:
P-gp/BCRP-IN-2
T79353
Synonym:
Target:
Encequidar, HCl
T68568
Synonym:
Target:
Brivudine monophosphate
T68656
Synonym:
Target:
Estradiol 17-(β-D-Glucuronide) (sodium salt hydrate)
T36807
Synonym:
Target:
Coelenterazine hcp
T36847
Synonym:
Target:
Cat No. Product Name Synonyms Targets
TN1651 Furanodiene Apoptosis , PARP , Reactive Oxygen Species , Caspase , CDK , P-gp
Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
T3S0012 Coniferyl ferulate P-gp , GST
Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis. It shows strong inhibition of human placental GST (IC50: 0.3 μM). It also reverses multidrug resistance ...
T2S0223 Isosinensetin 6-Demethoxynobiletin Antioxidant , HIV Protease , Antibacterial , P-gp
1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.
TN4761 Phellamurin P-gp
Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadmini...
TJS1159 Chrysosplenetin Chrysosptertin B P450 , Ferroptosis , P-gp
Chrysosplenetin is a metabolic inhibitor of artemisinin.
T2S0271 Voacamine Voacanginine Cannabinoid Receptor , P-gp
Voacamine (Voacanginine) is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells.Voacangini...
T3002 Piperine 1-Piperoylpiperidine,Bioperine P450 , Endogenous Metabolite , P-gp , Autophagy
Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.
T2S1200 Sinapine Antioxidant , P-gp , AChE
1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant and radio-protective activities.
T4034 Solamargine Solamargin,δ-Solanigrine Apoptosis , p38 MAPK , P-gp , STAT
Solamargine (δ-Solanigrine) is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cel...
T3392 Sinapine thiocyanate P-gp , AChE
Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800). It is also a phenolic-chloine conjugates, acting as anti-o...
T2799 (20S)-Protopanaxadiol 20-Epiprotopanaxadiol,20(S)-APPD Apoptosis , Reactive Oxygen Species , P-gp
(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin.
TN1525 Convallatoxin NF-κB , P-gp , PPAR
Convallatoxin is a natural product
TN1757 Hypophyllanthin Potassium Channel , Calcium Channel , P-gp
Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.
T19768 γ-Tocotrienol gamma Tocotrienol,gammaTocotrienol,gamma-Tocotrienol,D-gamma-Tocotrienol,Plastochromanol Others
γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E. Itl is also a radioprotector, antioxidant. It shows antitumor and antihypertensive effects in vivo.
T4085 Paris saponin VII Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII Apoptosis , BCL , Others , PARP , p38 MAPK , Akt , Caspase , P-gp , Autophagy
Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
TCS2336 Evodine P-gp
1. Evodine has antinociceptive activity.
T2S0265 Robinin NSC 9222 TLR
Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expreβing MDR1/LR...
T5813 BYAKANGELICIN Reductase
BYAKANGELICIN,a main furanocoumarin constituent isolated and characterized as an aldose reductase inhibitor,and is effective for the treatment of sugar cataracts and diabetic neuropathy and hence might be useful as a lea...
TN3937 Ent-16alpha,17-Dihydroxyatisan-3-one P-gp
ent-16alpha,17-Dihydroxyatisan-3-one and ent-16alpha,17-dihydroxykauran-3-one have apoptosis induction activities on L5178 human MDR1 gene-transfected mouse lymphoma cells.
T72802 Spongionellol A
Spongionellol A is a MDR1 (p-glycoprotein) inhibitor. Spongionellol A has high cytotoxic activity and selectivity in prostate cancer cells by inducing caspase‑dependent apoptosis . Spongionellol A can be used in the rese...

Natural Products

Furanodiene
TN1651
Synonym:
Target: Apoptosis, PARP, Reactive Oxygen Species, Caspase, CDK, P-gp
coniferyl ferulate
T3S0012
Synonym:
Target: P-gp, GST
Isosinensetin
T2S0223
Synonym: 6-Demethoxynobiletin
Target: Antioxidant, HIV Protease, Antibacterial, P-gp
Phellamurin
TN4761
Synonym:
Target: P-gp
Chrysosplenetin
TJS1159
Synonym: Chrysosptertin B
Target: P450, Ferroptosis, P-gp
Voacamine
T2S0271
Synonym: Voacanginine
Target: Cannabinoid Receptor, P-gp
Piperine
T3002
Synonym: 1-Piperoylpiperidine,Bioperine
Target: P450, Endogenous Metabolite, P-gp, Autophagy
Sinapine
T2S1200
Synonym:
Target: Antioxidant, P-gp, AChE
Solamargine
T4034
Synonym: Solamargin,δ-Solanigrine
Target: Apoptosis, p38 MAPK, P-gp, STAT
Sinapine thiocyanate
T3392
Synonym:
Target: P-gp, AChE
(20S)-Protopanaxadiol
T2799
Synonym: 20-Epiprotopanaxadiol,20(S)-APPD
Target: Apoptosis, Reactive Oxygen Species, P-gp
Convallatoxin
TN1525
Synonym:
Target: NF-κB, P-gp, PPAR
Hypophyllanthin
TN1757
Synonym:
Target: Potassium Channel, Calcium Channel, P-gp
γ-Tocotrienol
T19768
Synonym: gamma Tocotrienol,gammaTocotrienol,gamma-Tocotrienol,D-gamma-Tocotrienol,Plastochromanol
Target: Others
Paris saponin VII
T4085
Synonym: Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII
Target: Apoptosis, BCL, Others, PARP, p38 MAPK, Akt, Caspase, P-gp, Autophagy
Evodine
TCS2336
Synonym:
Target: P-gp
Robinin
T2S0265
Synonym: NSC 9222
Target: TLR
BYAKANGELICIN
T5813
Synonym:
Target: Reductase
ent-16alpha,17-Dihydroxyatisan-3-one
TN3937
Synonym:
Target: P-gp
Spongionellol A
T72802
Synonym:
Target:

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-03139 MDR1 Protein, Plasmodium falciparum, Recombinant (His & SUMO) Plasmodium falciparum E. coli
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
TMPH-01614 LDHC Protein, Human, Recombinant (His & SUMO) Human E. coli
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentia...
TMPH-02673 GFAP Protein, Mouse, Recombinant (His & SUMO) Mouse E. coli
DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation. Predominantly acts as a RNA-binding protein: binds ...
TargetMol