Search Result

Search Results for " ibd "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T1752	NS6180		Potassium Channel
	NS6180 is a potent and selective KCa3.1 channel inhibitor(IC50= 9 nM). It prevents T-cell activation and inflammation.		Potassium Channel
T4084	Sibofimloc	VRT-1353385,Antibiotic-202,Antibiotic 202	Antibacterial , Antibiotic
	Sibofimloc (Antibiotic-202), an antibiotic compound, is used in treating bacterial infections.		Antibacterial , Antibiotic
T22338	2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide	GDC046	Others , JAK
	2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile.		Others , JAK
T2601	Vidofludimus	SC12267,4sc-101	Dehydrogenase , DNA/RNA Synthesis , Interleukin
	Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).		Dehydrogenase , DNA/RNA Synthesis , Interleukin
T13692	Ferric maltol	Iron(III) 2-methyl-4-oxo-4H-pyran-3-olate	Others
	Ferric maltol (Iron(III) 2-methyl-4-oxo-4H-pyran-3-olate) is a ferric, non-salt-based oral iron formulation demonstrating improved tolerance in patients with previous intolerance to other iron formulations.		Others
T19668	Tiomolibdate diammonium	Ammonium molybdenum sulfide,Ammonium tetrathiomolybdate,NSC 286644,ATTM,Coprexa	Others
	Tiomolibdate diammonium (NSC-286644) is an inhibitor of superoxide dismutase 1 (SOD1) exerting antiangiogenic and antitumor activities. Tiomolibdate diammonium inhibits the activities of cuproenzymes, including SOD1 and ...		Others
T74786	BIBD-124
	BIBD-124, with an IC50 value of 9.51 nM, effectively binds to amyloid beta (Aβ) plaques. The fluorinated variant, [18F]BIBD-124, serves as a radiotracer for imaging Aβ plaques [1].
T36402	Kibdelone C
	Kibdelone C is a member of a family of natural heterocyclic polyketides first isolated from a soil actinomycete, Kibdelosporangium. Kibdelones have been described as having potent and selective cytotoxicity against a pan...
T24997	ABT-510 acetate	ABT 510 acetate	Apoptosis
	ABT-510 acetate is an endogenous anti-angiogenic TSP peptide inhibitor, a thrombospondin analog, with anti-inflammatory, anti-cancer and anti-angiogenic activity that induces apoptosis and inhibits ovarian tumor growth i...		Apoptosis
T79600	Zharp2-1		RIP kinase
	Zharp2-1, a RIPK2 inhibitor, inhibits the transcription of inflammatory cytokines induced by MDP-induced or Listeria monocytogenes infection and alleviates MDP-induced peritonitis symptoms in mice, which can be used for ...		RIP kinase
T9975	GPR183	3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide	Others
	GPR183 (3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide) is a chemotactic receptor known for its role in the maturation of B cells, and the endogenous ligand is the oxysterol 7α,25-dihydroxycholes...		Others
T38944	Tetomilast	OPC-6535,Tetomilast
	Tetomilast (OPC-6535) is a phosphodiesterase-4 (PDE4) inhibitor, potentially effective in treating inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD).
T4666	TCJL37
	TCJL37, a potent, selective, and orally bioavailable inhibitor of TYK2, exhibits a K i value of 1.6 nM. It is useful for researching inflammatory bowel diseases (IBD) [1].
T79385	PDE1-IN-5
	PDE1-IN-5 (Compound 10c) is a selective PDE1C inhibitor with an IC50 of 15 nM, exhibiting anti-inflammatory properties through the inhibition of iNOS, TNF-α, IL-1α, IL-1β, and IL-6 expression induced by LPS. It has demon...
T62462	RORγt/DHODH-IN-2
	RORγt/DHODH-IN-2 (compound 1) is a potent dual RORγt/DHODH inhibitor that can be used in the study of inflammatory bowel disease (IBD).
T7749	ALB-127158
	ALB-127158(a) is a potent and selective melanin concentrating hormone 1 ( MCH 1 ) receptor antagonist which may be a potential treatment for inflammatory bowel disease (IBD).
T82223	HDHODH-IN-13
	hDHODH-IN-13 (compound w2), an inhibitor of human dihydroorotate dehydrogenase (hDHODH), exhibits an IC50 of 173.4 nM and has potential research applications in studying inflammatory bowel disease (IBD) [1].
T76737	Abrilumab
	Abrilumab, a fully human monoclonal antibody, targets the α4β7 integrin heterodimer, selectively binding to it. This specificity makes it a potential research tool for investigating inflammatory bowel disease (IBD) [1].
T76057	Glepaglutide acetate
	Glepaglutide (ZP1848) acetate is a long-acting glucagon-like peptide-2 (GLP-2) analogue and a potent GLP-2 receptor (GLP-2R) agonist. It significantly reduces fecal output and enhances intestinal absorption while also mi...
T77154	Etrolizumab
	Etrolizumab (rhuMAb Beta7), a gut-selective anti-β7 integrin monoclonal antibody, targets the β7 subunit of α4β7 and αEβ7 integrins specifically, demonstrating affinity with K i values of 18 nM for Human α4β7 and 1800 pM...
T76056	Glepaglutide
	Glepaglutide (ZP1848), a long-acting glucagon-like peptide-2 (GLP-2) analogue, functions as a potent agonist of the GLP-2 receptor (GLP-2R), effectively reducing fecal output and enhancing intestinal absorption, while al...
T70899	Vidofludimus hemicalcium	4sc-101 hemicalcium,SC12267 hemicalcium,4sc-101 hemicalcium ; SC12267 hemicalcium
	Vidofludimus hemicalcium (4sc-101; SC12267) is an orally active compound that acts as a dihydroorotate dehydrogenase (DHODH) inhibitor and serves as a novel modulator of the farnesoid X receptor (FXR). This immunomodulat...
T79527	BET BD2-IN-1		Epigenetic Reader Domain
	BET BD2-IN-1 (compound 45) is a potent, selective inhibitor of BET BD2, exhibiting an IC50 value of 1.6 nM. It suppresses Th17 cell differentiation through the reduced activation of STAT3 and NF-κB, making it relevant in...		Epigenetic Reader Domain
T62556	JAK-IN-23
	JAK-IN-23 is an orally active dual JAK/STAT and NF-κB inhibitor that inhibits J AK1 (IC50: 8.9 nM), J AK2 (IC50: 15 nM), and J AK3 (IC50: 46.2 nM). JAK-IN-23 exhibits strong anti-inflammatory effects and can reduce the r...
T78084	PSB 0777 ammonium hydrate		Adenosine Receptor
	PSB 0777 ammonium hydrate is a potent and selective adenosine A2A receptor full agonist, exhibiting K i values of 44.4 nM for rat A2A receptors and 360 nM for human A2A receptors. For rat and human A1 receptors, it shows...		Adenosine Receptor
T36660	Olsalazine-13C6	Olsalazine-13C6
	Olsalazine-13C6is intended for use as an internal standard for the quantification of olsalazine by GC- or LC-MS. Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid that...

Compounds

NS6180

T1752

Synonym:

Target: Potassium Channel

Sibofimloc

T4084

Synonym: VRT-1353385,Antibiotic-202,Antibiotic 202

Target: Antibacterial, Antibiotic

2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide

Synonym: SC12267,4sc-101

Target: Dehydrogenase, DNA/RNA Synthesis, Interleukin

Ferric maltol

T13692

Synonym: Iron(III) 2-methyl-4-oxo-4H-pyran-3-olate

Target: Others

Tiomolibdate diammonium

T19668

Synonym: Ammonium molybdenum sulfide,Ammonium tetrathiomolybdate,NSC 286644,ATTM,Coprexa

Synonym: ABT 510 acetate

Synonym: 3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide

Target: Others

Tetomilast

T38944

Synonym: OPC-6535,Tetomilast

Vidofludimus hemicalcium

T70899

Synonym: 4sc-101 hemicalcium,SC12267 hemicalcium,4sc-101 hemicalcium ; SC12267 hemicalcium

Target: Epigenetic Reader Domain

PSB 0777 ammonium hydrate

T78084

Synonym:

Target: Adenosine Receptor

Olsalazine-13C6

T36660

Synonym: Olsalazine-13C6

Target:

Cat No.	Product Name	Synonyms	Targets
T2718	Palmatine chloride		Others , Indoleamine 2,3-Dioxygenase (IDO) , Aurora Kinase
	Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.		Others , Indoleamine 2,3-Dioxygenase (IDO) , Aurora Kinase
T5S0802	Palmatine	Berbericinine,Burasaine	Indoleamine 2,3-Dioxygenase (IDO) , AChR , AChE , Aurora Kinase
	1. Palmatine (Burasaine) is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has been used in the treatment of jaundice, dysentery,...
T4939	Indole-3-pyruvic acid	3-(3-Indolyl)-2-oxopropanoic acid	Others
	Indole-3-pyruvic acid (3-(3-Indolyl)-2-oxopropanoic acid) is a compound involved in the biosynthesis of Indole-3-acetic acid, a plant hormone which plays important roles in regulating growth and responses to environmenta...		Others

Natural Products

Palmatine chloride

T2718

Synonym:

Target: Others, Indoleamine 2,3-Dioxygenase (IDO), Aurora Kinase

Palmatine

T5S0802

Synonym: Berbericinine,Burasaine

Target: Indoleamine 2,3-Dioxygenase (IDO), AChR, AChE, Aurora Kinase

Indole-3-pyruvic acid

T4939

Synonym: 3-(3-Indolyl)-2-oxopropanoic acid

Target: Others

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPK-00353	IL-23R Protein, Human, Recombinant (aa 24-355, His)	Human	HEK293
	Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex cons...
TMPK-00575	IL-23R Protein, Canine, Recombinant (His)	Canine	HEK293
	Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex cons...
TMPK-00652	IL-23R Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex cons...
TMPK-01094	IL-23R Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex cons...
TMPK-00537	IL-10R alpha/IL-10RA Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	The interleukin-10 receptor alpha (IL10RA) gene codes for the alpha chain of the IL-10 receptor which binds the cytokine IL-10. IL-10 is an anti-inflammatory cytokine with immunoregulatory function during the pathogenesi...
TMPK-00335	IL-10R alpha/IL-10RA Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	The interleukin-10 receptor alpha (IL10RA) gene codes for the alpha chain of the IL-10 receptor which binds the cytokine IL-10. IL-10 is an anti-inflammatory cytokine with immunoregulatory function during the pathogenesi...
TMPK-00334	IL-10R alpha/IL-10RA Protein, Human, Recombinant (His & Avi)	Human	HEK293
	The interleukin-10 receptor alpha (IL10RA) gene codes for the alpha chain of the IL-10 receptor which binds the cytokine IL-10. IL-10 is an anti-inflammatory cytokine with immunoregulatory function during the pathogenesi...
TMPK-01011	TNFSF15 Protein, Mouse, Recombinant (His & Avi)	Mouse	HEK293
	TL1A and its functional receptor DR3 are members of the TNF/TNFR superfamilies of proteins.TL1A and DR3 are abundantly localized at inflamed intestinal areas of patients with IBD and mice with experimental ileitis or col...
TMPK-01013	TNFSF15 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	TL1A and its functional receptor DR3 are members of the TNF/TNFR superfamilies of proteins.TL1A and DR3 are abundantly localized at inflamed intestinal areas of patients with IBD and mice with experimental ileitis or col...
TMPK-01012	TNFSF15 Protein, Mouse, Recombinant (His & Avi), Biotinylated	Mouse	HEK293
	TL1A and its functional receptor DR3 are members of the TNF/TNFR superfamilies of proteins.TL1A and DR3 are abundantly localized at inflamed intestinal areas of patients with IBD and mice with experimental ileitis or col...
TMPY-04282	Fas/CD95 Protein, Rat, Recombinant (hFc)	Rat	HEK293
	CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized...
TMPY-01426	Fas/CD95 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized...
TMPY-03834	Fas/CD95 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293
	CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized...
TMPY-00799	Fas/CD95 Protein, Human, Recombinant (hFc)	Human	HEK293
	CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized...
TMPY-02057	Fas/CD95 Protein, Rat, Recombinant (His)	Rat	HEK293
	CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized...
TMPY-01704	Fas/CD95 Protein, Human, Recombinant (His)	Human	HEK293
	CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized...
TMPY-00632	Fas/CD95 Protein, Cynomolgus, Recombinant	Cynomolgus	HEK293
	CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized...
TMPY-04828	TFF3 Protein, Human, Recombinant (His)	Human	HEK293
	Trefoil factor family (TFF) peptides are involved in the maintenance of epithelial integrity and epithelial restitution. Trefoil factor-3 (TFF3) is an estrogen-regulated gene associated with prognosis in different types ...