cdk8 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T72029	CDK8-IN-13		Apoptosis , CDK
	CDK8-IN-13 is a CDK8 inhibitor (IC50: 51.9 nM) with potent, selective and oral activity. CDK8-IN-13 induces apoptosis and reduces the expression of p-STAT1 S727 and p-STAT5 S726. CDK8-IN-13 exhibits anti-tumour activity...		Apoptosis , CDK
T10740	CDK8-IN-1		CDK
	CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).		CDK
T72048	CDK8-IN-12		GSK-3 , CDK
	CDK8-IN-12 is a selective, potent and orally active inhibitor of CDK8 (Ki: 14 nM) and is an anti-cancer agent. CDK8-IN-12 inhibits GSK-3α, GSK-3β and PCK-θ with Ki of 13 nM, 4 nM and 109 nM respectively. CDK8-IN-12 showe...		GSK-3 , CDK
T10739	CDK8/19-IN-1		CDK
	CDK8/19-IN-1 is a selective and oral bioavailable CDK8/19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9).		CDK
T17305	CDK8-IN-4		CDK
	CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM).		CDK
T14917	CDK8-IN-3		Others
	CDK8-IN-3 is an inhibitor of CDK8.		Others
T70148	CDK8-IN-4k
	CDK8-IN-4k is a potent and highly selective CDK8 inhibitor, with no apparent potential for time-dependent CYP3A4 inhibition.
T70098	CDK8-IN-18
	CDK8-IN-18, also known as ZINC584617986, is a potent and selective inhibitor of CDK8, also modulating CDK19.
T62310	CDK8-IN-5
	CDK8-IN-5 is a potent inhibitor of CDK8, exhibiting an inhibitory concentration (IC 50) of 72 nM. Demonstrating anti-inflammatory properties, it achieves a 43% enhancement rate of IL-10. This compound holds potential for...
T62112	CDK8-IN-6
	CDK8-IN-6 (compound 9) is a potent inhibitor of cyclin-dependent kinase 8 (CDK8) (Kd: 13 nM), CDK8-IN-6 showed potential research value in AML cancers.
T63690	CDK8-IN-10
	CDK8-IN-10 is a selective and potent inhibitor of cell cycle protein-dependent kinase (CDK8) (IC50: 8.25 nM) that can be used to study cancer.
T61742	CDK8-IN-11
	CDK8-IN-11 is a potent and selective inhibitor of CDK8, demonstrating an IC50 of 46 nM, and effectively targets the WNT/β-catenin signaling pathway. This compound has potential applications in colon cancer research [1].
T64245	CDK8-IN-9
	CDK8-IN-9 (compound 22) is a potent inhibitor of type II CDK8 (IC50: 48.6 nM) and has shown inhibitory effects on tumour growth. CDK8-IN-9 can be used to study colorectal cancer.
T62354	CDK8-IN-7
	CDK8-IN-7 (compound 12) is a potent and selective inhibitor of cyclin-dependent kinase 8 (CDK8) (Kd: 3.5 nM). CDK8-IN-7 has shown potential for AML-cancer research.
T62293	CDK8-IN-11 hydrochloride
	CDK8-IN-11 hydrochloride is a selective and potent inhibitor of CDK8 (IC50: 46 nM). CDK8-IN-11 hydrochloride inhibits the WNT/β-catenin signalling pathway. CDK8-IN-11 hydrochloride can be used to study colon cancer.
T71908	NU1085
	NU1085 is a potent poly(ADP-ribose) polymerase (PARP) inhibitors have been developed that potentiate the cytotoxicity of ionizing radiation and anticancer drugs. The biological effects of NU1085 [Ki = 6 nM], in combinati...
T21678	3MB-PP1		PLK
	3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor. In cells expressing analog-sensitive Plk1 alleles, 3MB-PP1 blocks mitotic progression and cell division arise by targeting Plk1. 3MB-PP1 specifi...		PLK
T70147	Fipravirimat
	Fipravirimat is a potent inhibitor of HIV-1 with potential applications in HIV and AIDS research.
T14778	BRD6989		IL Receptor , CDK , Interleukin
	BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes. BRD6989 selectively binds a complex...		IL Receptor , CDK , Interleukin
T8430	Senexin B		CDK
	Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM).		CDK
TQ0266	MSC2530818		CDK
	MSC2530818 is an effective, selective and orally available CDK8 inhibitor (IC50: 2.6 nM).		CDK
T5405	BI-1347		CDK
	BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model.		CDK
T5673	Senexin A		CDK
	Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively.		CDK
T14901	CCT-251921		CDK
	CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).		CDK
T10744L	SEL120-34A HCl		CDK
	SEL120-34A HCl is a selective, orally available and ATP-competitive inhibitor of CDK8(CDK8/CycC and CDK19/CycC with IC50s of 4.4 nM and 10.4 nM , respectively), with antitumor activity.		CDK
T10744	SEL120-34A		CDK
	SEL120-34A is a selective and ATP-competitive inhibitor of CDK8 with IC50s of 4.4 nM, 10.4 nM and 1070 nM for CDK8/CycC, CDK19/CycC and CDK9/cycT. SEL120-34A possesses antitumor activity.		CDK
TQ0060	LY2857785		Apoptosis , CDK
	LY2857785 is a type I competitive and reversible ATP kinase inhibitor against CDK7/CDK8/CDK9 (IC50s: 246 nM/16 nM/11 nM).		Apoptosis , CDK
T62702	Senexin C		CDK
	Senexin C is a novel orally active and specific CDK8/19 inhibitor with potential anticancer activity.Senexin C is more metabolically stable and potent than Senexin B. Senexin C inhibits the growth of MV4-11 leukaemia cel...		CDK
T8378	AS2863619		CDK , STAT
	AS2863619 is an orally active inhibitor of cyclin-dependent kinase 8 (CDK8) and CDK19 (IC50s of 0.61 nM and 4.28 nM, respectively).		CDK , STAT
T14907	CCT251545		Wnt/beta-catenin
	CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).		Wnt/beta-catenin
T13743	JH-XI-10-02		EGFR
	JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC.		EGFR
T40280	JH-XVI-178
	JH-XVI-178 is a highly potent and selective CDK8/19 inhibitor with favorable pharmacokinetic attributes, including low clearance and moderate oral bioavailability.
T10382	AS2863619 free base		CDK
	AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells. It is a potent, orally active CDK8 and CDK19 inhibitor (IC50s: 0.61 nM and 4.28 nM). STAT5 act...		CDK
T24811	SNX2-1-108	SNX-21108,SNX21108,SNX 21108
	SNX2-1-108 is a selective CDK8 and CDK19 inhibitor.
T81137	SNX7886		PROTACs
	SNX7886 is a potent PROTAC (proteolysis-targeting chimera) that effectively degrades CDK8 and CDK19, achieving 90% degradation of CDK8 and 80% degradation of CDK19 in 293 cells [1].		PROTACs
T22633	CCT251545 analogue, Compound 51		Others
	CCT251545 analog is a potent and selective CDK8/19 inhibitor (IC50: 5.1 nM and 5.6 nM, respectively). Mediator complex-associated kinases CDK8 and CDK19 are involved in the regulation of multiple transcription pathways. ...		Others
T23909	Cortistatin A	Cortistatin-A
	Cortistatin A is a potent and selective mediator-associated kinase CDK8 and its paralogue CDK19 inhibitor.
T24200	JH-VIII-49	JH-VIII49,JH-VIII 49,JHVIII-49,JHVIII 49,JHVIII49
	JH-VIII-49 is an effective and selective inhibitor of CDK8.
T61590	DS96432529
	DS96432529 is a potent and orally active bone anabolic agent through CDK8 inhibition.
T68758	UNC10112785
	UNC10112785 is a novel potent inhibitor of CDK8, CDK19, and CDK9 with IC50 at 1.05, 2.67, and 19.9 nM, respectively, causing MYC loss through both transcriptional and posttranslational mechanisms, and suppressing PDAC an...
T74784	LL-K8-22
	LL-K8-22 is a potent, selective, and durable dual degrader of CDK8-cyclin C, demonstrating DC50 values of 2.52 and 2.64 μM, respectively. This compound effectively suppresses STAT1 Ser 727 phosphorylation and inhibits ca...

Compounds

CDK8-IN-13

T72029

Synonym:

Target: Apoptosis, CDK

CDK8-IN-11 hydrochloride

Target: IL Receptor, CDK, Interleukin

Target: Apoptosis, CDK

Target: Wnt/beta-catenin

Synonym: SNX-21108,SNX21108,SNX 21108

CCT251545 analogue, Compound 51

Synonym: Cortistatin-A

Target:

JH-VIII-49

T24200

Synonym: JH-VIII49,JH-VIII 49,JHVIII-49,JHVIII 49,JHVIII49

Cat No.	Product Name	Synonyms	Targets
T2933	Wogonin	Vogonin	Apoptosis , Wnt/beta-catenin , CDK , Autophagy
	Wogonin (Vogonin) is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties.		Apoptosis , Wnt/beta-catenin , CDK , Autophagy

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