2-linoleoyl glycerol

2-Arachidonoyl glycerol (2-AG), a natural endocannabinoid ligand for the CB1 receptor, was isolated from porcine brain and characterized. Its congener, 2-linoleoyl glycerol (2-LG), which has a linoleoyl group instead of an arachidonoyl group, also exists alongside 2-AG in vivo. While 2-LG exhibits low intrinsic activity, it enhances the activity of 2-AG and other endocannabinoids through an "entourage" effect, attributed to the inhibition of breakdown and reuptake pathways that typically decrease endocannabinoid levels post-release.

1,3-Dipalmitoyl-2-linoleoyl glycerol is a triacylglycerol featuring palmitic acid at the sn-1 and sn-3 positions, and linoleic acid at the sn-2 position. Identified within the palm stearin fraction of palm oil and as a trace constituent in soybean germ oil, this compound exemplifies the structural diversity of fats and oils in both plant-based sources.

1,3-Dioleoyl-2-linoleoyl glycerol, a triacylglycerol, features oleic acid at the sn-1 and sn-3 positions and linoleic acid at the sn-2 position. This compound is a prominent species in butterfat and is present in A. trifoliata seed oil (ASO), along with smaller amounts in its physical blends and interesterified products.

1,3-Distearoyl-2-linoleoyl glycerol, a triacylglycerol, features stearic acid at the sn-1 and sn-3 positions and linoleic acid at the sn-2 position. This compound is present in cocoa butter and in cocoa butter equivalents (CBEs) that include shea stearin and palm mid fraction.

1-Stearoyl-2-linoleoyl-3-oleoyl-rac-glycerol is a triglyceride composed of Stearic acid at the sn-1 position, Linoleic acid at the sn-2 position, and Oleic acid at the sn-3 position.

1-Oleoyl-2-linoleoyl-rac-glycerol (DG(18:1/0:0/18:2)) is a diacylglycerol composed of linoleic acid and oleic acid. This compound can be found in dry-cured ham and acts as a flavoring agent in food.

1-Palmitoyl-2-oleoyl-3-linoleoyl-rac-glycerol (POL) is a common triglyceride component found in various vegetable oils, suitable for biochemical experiments and vegetable oil analysis.

1-Myristoyl-2-linoleoyl-3-palmitoyl-rac-glycerol, a triacylglycerol comprising myristic, linoleic, and palmitic acids at the sn-1, sn-2, and sn-3 positions respectively, is present in palm and vegetable oils.

1-Myristoyl-2-linoleoyl-3-oleoyl-rac-glycerol, a triacylglycerol, features myristic acid, linoleic acid, and oleic acid at the sn-1, sn-2, and sn-3 positions, respectively. This compound is prevalent in mature human milk, infant formula fats, and butterfat.

1-Stearoyl-2-oleoyl-3-linoleoyl-rac-glycerol is a triacylglycerol consisting of stearic acid, oleic acid, and linoleic acid esterified at the sn-1, sn-2, and sn-3 positions, respectively. This compound is present in peanut and soybean oils as well as in ostrich and emu oils. Additionally, it serves as a substrate for soybean lipoxygenase in cell-free assays.

1-Palmitoyl-2-elaidoyl-3-linoleoyl-rac-glycerol is a triacylglycerol composed of palmitic acid (at the sn-1 position), elaidic acid (at the sn-2 position), and linoleic acid (at the sn-3 position) respectively.

1-Palmitoyl-2-linoleoyl-3-stearoyl-rac-glycerol, a triacylglycerol, comprises palmitic acid (at the sn-1 position), linoleic acid (at the sn-2 position), and stearic acid (at the sn-3 position). This compound is present in mature human milk and various plant oils.

1-Oleoyl-2-palmitoyl-3-linoleoyl-rac-glycerol is a triacylglycerol comprising oleic acid [at the sn-1 position], palmitic acid [at the sn-2 position], and linoleic acid [at the sn-3 position], identified in bovine milk fat.

1-Linoleoyl-2-oleoyl-3-stearoyl-rac-glycerol is a triglyceride molecule known for its biological activity in promoting lipid droplet formation. The unique combination of fatty acids in 1-Linoleoyl-2-oleoyl-3-stearoyl-rac-glycerol makes it a valuable tool for studying the roles of fatty acids. It finds extensive application in cell biology and metabolic research.

1-Linoleoyl-2-oleoyl-rac-glycerol is a diglyceride containing Oleic acid and Linoleic acid.

1-Palmitoyl-2-linoleoyl-rac-glycerol is a diacylglycerol containing Palmitic acid.

1-Oleoyl-2-linoleoyl-sn-glycerol is a diacylglycerol (DG) that can activate protein kinase C (PKC), initiating downstream signaling cascades that promote tumor growth. This compound shows potential for use in breast cancer research.

1-Palmitoyl-2-linoleoyl-sn-glycerol is a diacylglycerol (DAG) lipid signaling molecule that can be found in the coralloid roots of the plant Cycas revoluta.

1-Stearoyl-2-linoleoyl-sn-glycerol is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis. Oxaliplatin causes DNA cross-linking damage, preventing DNA replication and transcription and leading to cell death. Oxaliplatin induces autophagy.

Gemcitabine (LY188011) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis.

Cyclosporin A is a natural product and an active fungal metabolite, classified as a cyclic polypeptide immunosuppressant. It binds to cyclophilin and inhibits the activity of calcineurin (IC₅₀ = 7 nM) as well as CD11a/CD18 adhesion molecules. It is commonly used to induce uremia models.

Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic activity. Decitabine induces cell cycle arrest and apoptosis.

Erastin is an iron death activator that acts on the mitochondrial VDAC in a ROS- and iron-dependent manner. Erastin has anti-tumor activity and acts selectively on tumor cells with RAS-carcinogenic mutations.