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TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN3692 Conduritol A 526-87-4 98%
Conduritol A
Conduritol A has a hypoglycemic effect, can have an effect on regulating the metabolism of blood lipid, free-radical scavenging, enhancing the antioxidant abilit...
TN4581 Moracin D 69120-07-6 98%
Moracin D
Moracin C and moracin D, new phytoalexins from diseased mulberry, are antifungal compounds. Moracin may be protective influence in tumor promotion, utilization o...
TN1960 Mussaenoside 64421-27-8 98%
Mussaenoside
Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB.
T17107 TMC353121 857066-90-1 98%
TMC353121
TMC353121 is a respiratory syncytial virus (RSV) fusion inhibitor with anti-RSV activity that inhibits the production of the inflammatory cytokines TNF-α, IL-6, ...
TN4648 Nepetoidin B 55486-06-1 98%
Nepetoidin B
Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly via modulation of iNOS mediated ...
TMA0627 Taxiresinol 40951-69-7 98%
Taxiresinol
Taxiresinol shows anticancer, antinociceptive, and antiallergic activities, it shows inhibitory activity on induced histamine release from the human basophilic c...
T5768 Bruceine B 25514-29-8 98%
bruceine B
Bruceine B, a potent inhibitor of leukocyte-endothelial cell adhesion, may have anti-inflammatory activity, it can inhibit neutrophil adhesion to lipopolysacchar...
TN3245 7-O-Methylmorroniside 119943-46-3 98%
7-O-Methylmorroniside
7-O-Methylmorroniside exhibits anti-inflammatory activity.
T14312 Apratastat 287405-51-0 98%
Apratastat
Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) an...
T16755 RIPK-IN-4 2141969-56-2 98%
RIPK-IN-4
RIPK-IN-4 is an effective and selective inhibitor of RIPK2. It also has excellent oral bioavailability (IC50: 3 nM).
TN5264 Xanthoxyletin 84-99-1 98%
Xanthoxyletin
Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory ...
TN1242 3,3'-Di-O-methylellagic acid 2239-88-5 98%
3,3'-Di-O-methylellagic acid
3,3'-Di-O-methylellagic acid reveals moderate antibacterial activity, it also shows strong DPPH radical scavenging activities with SC50 of 123.3 ug/mL. It has a ...
TN1359 Aflatoxin G1 1165-39-5 98%
Aflatoxin G1
Aflatoxin G1 (AFG1 ), a member of the AF family with cytotoxic and carcinogenic properties, could cause DNA damage in alveolar type II (AT-II) cells and induce l...
TN2224 Soyasapogenol A 508-01-0 98%
Soyasapogenol A
Soyasapogenol A shows estrogenic and hepatoprotective activities, it directly prevents apoptosis of hepatocytes, and secondly, inhibits the elevation of plasma T...
TN3517 Bisacurone 120681-81-4 98%
Bisacurone
Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressi...
TN4409 Lansiumarin C 205115-75-9 98%
Lansiumarin C
Lansiumarin C can decrease nitric oxide (NO) and tumor necrosis factor-α (TNF-α) production in lipopolysaccharide (LPS)-induced macrophages.
T12202 Nec-4 1041644-43-2 98%
Nec-4
Nec-4 is a potent inhibitor of receptor interacting protein 1 (RIP1)(IC50 of 2.6 μM),and is a tricyclic derivative.
TN5138 Teuclatriol 152110-17-3 98%
Teuclatriol
Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-κB signaling at doses of 312...
TN1227 25R-Inokosterone 19682-38-3 98%
25R-Inokosterone
25R-Inokosterone exhibits potent inhibition against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells. 25R-Inokosterone has ex...
TN3614 Cearoin 52811-37-7 98%
Cearoin
Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
Conduritol A
TN3692
Conduritol A has a hypoglycemic effect, can have an effect on regulating the metabolism of blood lipid, free-radical scavenging, enhancing the antioxidant abilit...
Moracin D
TN4581
Moracin C and moracin D, new phytoalexins from diseased mulberry, are antifungal compounds. Moracin may be protective influence in tumor promotion, utilization o...
Mussaenoside
TN1960
Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB.
TMC353121
T17107
TMC353121 is a respiratory syncytial virus (RSV) fusion inhibitor with anti-RSV activity that inhibits the production of the inflammatory cytokines TNF-α, IL-6, ...
Nepetoidin B
TN4648
Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly via modulation of iNOS mediated ...
Taxiresinol
TMA0627
Taxiresinol shows anticancer, antinociceptive, and antiallergic activities, it shows inhibitory activity on induced histamine release from the human basophilic c...
bruceine B
T5768
Bruceine B, a potent inhibitor of leukocyte-endothelial cell adhesion, may have anti-inflammatory activity, it can inhibit neutrophil adhesion to lipopolysacchar...
7-O-Methylmorroniside
TN3245
7-O-Methylmorroniside exhibits anti-inflammatory activity.
Apratastat
T14312
Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) an...
RIPK-IN-4
T16755
RIPK-IN-4 is an effective and selective inhibitor of RIPK2. It also has excellent oral bioavailability (IC50: 3 nM).
Xanthoxyletin
TN5264
Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory ...
3,3'-Di-O-methylellagic acid
TN1242
3,3'-Di-O-methylellagic acid reveals moderate antibacterial activity, it also shows strong DPPH radical scavenging activities with SC50 of 123.3 ug/mL. It has a ...
Aflatoxin G1
TN1359
Aflatoxin G1 (AFG1 ), a member of the AF family with cytotoxic and carcinogenic properties, could cause DNA damage in alveolar type II (AT-II) cells and induce l...
Soyasapogenol A
TN2224
Soyasapogenol A shows estrogenic and hepatoprotective activities, it directly prevents apoptosis of hepatocytes, and secondly, inhibits the elevation of plasma T...
Bisacurone
TN3517
Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressi...
Lansiumarin C
TN4409
Lansiumarin C can decrease nitric oxide (NO) and tumor necrosis factor-α (TNF-α) production in lipopolysaccharide (LPS)-induced macrophages.
Nec-4
T12202
Nec-4 is a potent inhibitor of receptor interacting protein 1 (RIP1)(IC50 of 2.6 μM),and is a tricyclic derivative.
Teuclatriol
TN5138
Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-κB signaling at doses of 312...
25R-Inokosterone
TN1227
25R-Inokosterone exhibits potent inhibition against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells. 25R-Inokosterone has ex...
Cearoin
TN3614
Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
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TargetMol