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Estrogen Receptor/ERR

The ERRs are orphan nuclear receptors, meaning the identity of their endogenous ligand has yet to be unambiguously determined. They are named because of sequence homology with estrogen receptors, but do not appear to bind estrogens or other tested steroid hormones.There are three human estrogen related receptors:ERRα,ERRβand ERRγ .
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T22794 G36 1392487-51-2 99.86%
G36
G36 is a cell-permeable non-steroidal antagonist of GPER. G36 inhibits activation by either 17β-estradiol or the GPER-selective agonist G-1 (IC50 = 112 and 165 n...
T39710 ARV-471 2229711-68-4 99.85%
ARV-471
ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.
T15248 Estetrol 15183-37-6 99.83%
Estetrol
Estetrol(Donesta) is an orally available, selective modulator of the estrogen receptor, a naturally occurring estrogen synthesized by the human fetal liver durin...
T6620 Ospemifene 128607-22-7 99.83%
Ospemifene
Ospemifene (FC-1271a) is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symp...
T1009 Estrone 53-16-7 99.82%
Estrone
Estrone (Aquacrine) is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE direct...
T2280 Endoxifen (Z-isomer) 112093-28-4 99.81%
Endoxifen (Z-isomer)
Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase ac...
T1549 Raloxifene hydrochloride 82640-04-8 99.81%
Raloxifene hydrochloride
Raloxifene hydrochloride (LY156758 hydrochloride) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopau...
T3385 Gypenoside XVII 80321-69-3 99.76%
Gypenoside XVII
Gypenoside XVII (Gynosaponin S) confers protection against Aβ25-35-induced neurotoxicity through estrogen receptor-dependent activation of PI3K/Akt pathways, act...
T0384 Estradiol benzoate 50-50-0 99.76%
Estradiol benzoate
Estradiol benzoate (Benzhormovarine) is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexu...
TN1148 Isopsoralenoside 905954-18-9 99.75%
Isopsoralenoside
Isopsoralenoside shows estrogen-like, osteoblastic proliferation accelerating, antitumor, and antibacterial effects.
T21387L Nafoxidine 1845-11-0 99.74%
Nafoxidine
Nafoxidine is an estrogen antagonist that has been used in the treatment of breast cancer.
TN1052 Lindleyin 59282-56-3 99.74%
Lindleyin
Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.
T0593 XCT790 725247-18-7 99.74%
XCT790
XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα).
T23540 Y134 849662-80-2 99.72%
Y134
Y134 is an estrogen receptor inhibitor that is selective and orally active, exhibiting strong antagonist activity against ERα and Erβ with Ki of 0.09 nM and 11....
T3325 Liquiritigenin 578-86-9 99.7%
Liquiritigenin
Liquiritigenin (4',7-Dihydroxyflavanone), a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist.
T2567 Etonogestrel 54048-10-1 99.69%
Etonogestrel
Etonogestrel (Implanon) is a steroidal progestin used as hormonal contraceptives.
T3840 Dihydroresveratrol 58436-28-5 99.68%
Dihydroresveratrol
Dihydroresveratrol (3,4',5-Trihydroxybibenzyl) is a major metabolite of resveratrol that is produced by animal-associated bacteria, including the gut microbiota....
T78646 Estrogen receptor antagonist 8 2889370-92-5 99.66%
Estrogen receptor antagonist 8
Estrogen Receptor Antagonist 8 exhibits potent antagonistic activity against the estrogen receptor (ER), demonstrating effective anti-uterotrophic potential in v...
T3806 Kaempferide 491-54-3 99.66%
kaempferide
kaempferide (4'-Methylkaempferol) inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not media...
T4281 Endoxifen 110025-28-0 99.66%
Endoxifen
(E/Z)-Endoxifen ((E/Z)-Endoxifen) is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It ...
G36
T22794
G36 is a cell-permeable non-steroidal antagonist of GPER. G36 inhibits activation by either 17β-estradiol or the GPER-selective agonist G-1 (IC50 = 112 and 165 n...
ARV-471
T39710
ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.
Estetrol
T15248
Estetrol(Donesta) is an orally available, selective modulator of the estrogen receptor, a naturally occurring estrogen synthesized by the human fetal liver durin...
Ospemifene
T6620
Ospemifene (FC-1271a) is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symp...
Estrone
T1009
Estrone (Aquacrine) is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE direct...
Endoxifen (Z-isomer)
T2280
Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase ac...
Raloxifene hydrochloride
T1549
Raloxifene hydrochloride (LY156758 hydrochloride) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopau...
Gypenoside XVII
T3385
Gypenoside XVII (Gynosaponin S) confers protection against Aβ25-35-induced neurotoxicity through estrogen receptor-dependent activation of PI3K/Akt pathways, act...
Estradiol benzoate
T0384
Estradiol benzoate (Benzhormovarine) is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexu...
Isopsoralenoside
TN1148
Isopsoralenoside shows estrogen-like, osteoblastic proliferation accelerating, antitumor, and antibacterial effects.
Nafoxidine
T21387L
Nafoxidine is an estrogen antagonist that has been used in the treatment of breast cancer.
Lindleyin
TN1052
Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.
XCT790
T0593
XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα).
Y134
T23540
Y134 is an estrogen receptor inhibitor that is selective and orally active, exhibiting strong antagonist activity against ERα and Erβ with Ki of 0.09 nM and 11....
Liquiritigenin
T3325
Liquiritigenin (4',7-Dihydroxyflavanone), a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist.
Etonogestrel
T2567
Etonogestrel (Implanon) is a steroidal progestin used as hormonal contraceptives.
Dihydroresveratrol
T3840
Dihydroresveratrol (3,4',5-Trihydroxybibenzyl) is a major metabolite of resveratrol that is produced by animal-associated bacteria, including the gut microbiota....
Estrogen receptor antagonist 8
T78646
Estrogen Receptor Antagonist 8 exhibits potent antagonistic activity against the estrogen receptor (ER), demonstrating effective anti-uterotrophic potential in v...
kaempferide
T3806
kaempferide (4'-Methylkaempferol) inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not media...
Endoxifen
T4281
(E/Z)-Endoxifen ((E/Z)-Endoxifen) is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It ...
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TargetMol