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Dehydrogenase

A dehydrogenase (also called DH or DHase in the literature) is an enzyme belonging to the group of oxidoreductases that oxidizes a substrate by reducing an electron acceptor, usually NAD+/NADP+ or a flavin coenzyme such as FAD or FMN. They also catalyze the reverse reaction, for instance alcohol dehydrogenase not only oxidizes ethanol to acetaldehyde in animals but also produces ethanol from acetaldehyde in yeast.
Cat. No. Product name CAS No. Purity Chemical Structure
T3542 BVT-14225 376638-65-2 98.14%
BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor (IC50=52 nM).
T9003 CVT-11127 1018674-83-3 98.15%
CVT-11127 is an StearoylCoA Desaturase-1 (SCD1) inhibitor.
T1979 AVN-944 297730-17-7 98.19%
AVN-944(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.
T1809 AGI-6780 1432660-47-3 98.19%
AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant.
T2901 Daidzin 552-66-9 98.28%
Daidzin is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.
T23533 WIN 18446 1477-57-2 98.41%
inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2)
T11765 KPLH1130 906669-07-6 98.43%
KPLH1130 improves glucose tolerance in HFD-fed mice. KPLH1130 is a specific pyruvate dehydrogenase kinase (PDK) inhibitor, blocks macrophage polarization and att...
T5S0620 3-Dehydrotrametenolic acid 29220-16-4 98.5%
1. Dehydrotrametenolic acid can be a potential anticancer agent against H-ras transformed tumor. 2. Dehydrotrametenolic acid is a promising candidate for a new t...
T0494 Tetramisole hydrochloride 5086-74-8 98.6%
Tetramisole is used as an anthelmintic.
T2447 AZD7545 252017-04-2 98.69%
AZD7545 is a potent PDHK inhibitor.
T8640 G6PDi-1 2457232-14-1 98.69%
G6PDi-1 is an effective G6PD inhibitor. It depletes NADPH and decreases inflammatory cytokine production.
T11029 HDHODH-IN-5 2029049-77-0 98.70%
hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH, IC50 = 0.91 μM).
T17224 VER-246608 1684386-71-7 98.88%
VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK...
T38683 SCD1 inhibitor-3 1282606-48-7 98.95%
SCD1 inhibitor-3 is a safe, potent and orally active SCD1 inhibitor. SCD1 inhibitor-3 can be used for the research of metabolic diseases such as obesity, type II...
T2043 Mutant IDH1-IN-1 1355326-21-4 98.98%
Mutant IDH1-IN-1 is a potent mutant IDH1 R132 h inhibitor with IC50 < 0.1 uM.
T22253 AG-120 (racemic) 1448346-63-1 98.99%
AG-120 (racemic), the racemic mixture of AG-120, is an orally available isocitrate dehydrogenase type 1 (IDH1) inhibitor, and shows potential antineoplastic acti...
T2650 MK-8245 1030612-90-8 99%
MK-8245 is a liver-targeting SCD inhibitor for human SCD1 (IC50: 1 nM) and for rat/mouse SCD1 (IC50: 3 nM), with anti-diabetic and anti-dyslipidemic function.
T2121 SW033291 459147-39-8 99.02%
SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.
T10525 SCD1 inhibitor-4 1295541-87-5 99.02%
SCD1 inhibitor-4 is stearoylCoA desaturase-1 (SCD1) inhibitor. SCD1 inhibitor-4 can be used for the research of diabetes.
T11025 HDHODH-IN-3 1644156-80-8 99.05%
hDHODH-IN-3 is an inhibitor of human dihydroorotate dehydrogenase with a pMIC50 value of 8.6. hDHODH-IN-3 can inhibit measles virus replication.
BVT-14225
T3542
BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor (IC50=52 nM).
CVT-11127
T9003
CVT-11127 is an StearoylCoA Desaturase-1 (SCD1) inhibitor.
AVN-944
T1979
AVN-944(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.
AGI-6780
T1809
AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant.
Daidzin
T2901
Daidzin is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.
WIN 18446
T23533
inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2)
KPLH1130
T11765
KPLH1130 improves glucose tolerance in HFD-fed mice. KPLH1130 is a specific pyruvate dehydrogenase kinase (PDK) inhibitor, blocks macrophage polarization and att...
3-Dehydrotrametenolic acid
T5S0620
1. Dehydrotrametenolic acid can be a potential anticancer agent against H-ras transformed tumor. 2. Dehydrotrametenolic acid is a promising candidate for a new t...
Tetramisole hydrochloride
T0494
Tetramisole is used as an anthelmintic.
AZD7545
T2447
AZD7545 is a potent PDHK inhibitor.
G6PDi-1
T8640
G6PDi-1 is an effective G6PD inhibitor. It depletes NADPH and decreases inflammatory cytokine production.
hDHODH-IN-5
T11029
hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH, IC50 = 0.91 μM).
VER-246608
T17224
VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK...
SCD1 inhibitor-3
T38683
SCD1 inhibitor-3 is a safe, potent and orally active SCD1 inhibitor. SCD1 inhibitor-3 can be used for the research of metabolic diseases such as obesity, type II...
Mutant IDH1-IN-1
T2043
Mutant IDH1-IN-1 is a potent mutant IDH1 R132 h inhibitor with IC50 < 0.1 uM.
AG-120 (racemic)
T22253
AG-120 (racemic), the racemic mixture of AG-120, is an orally available isocitrate dehydrogenase type 1 (IDH1) inhibitor, and shows potential antineoplastic acti...
MK-8245
T2650
MK-8245 is a liver-targeting SCD inhibitor for human SCD1 (IC50: 1 nM) and for rat/mouse SCD1 (IC50: 3 nM), with anti-diabetic and anti-dyslipidemic function.
SW033291
T2121
SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.
SCD1 inhibitor-4
T10525
SCD1 inhibitor-4 is stearoylCoA desaturase-1 (SCD1) inhibitor. SCD1 inhibitor-4 can be used for the research of diabetes.
hDHODH-IN-3
T11025
hDHODH-IN-3 is an inhibitor of human dihydroorotate dehydrogenase with a pMIC50 value of 8.6. hDHODH-IN-3 can inhibit measles virus replication.
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