undecanedioic acid

Undecanedioic acid has been found in parts of human aortas with advanced atherosclerotic lesions associated with intercellular matrix macromolecules and specifically with elastin.

369-Trioxaundecanedioic Acid, a PEG-based PROTAC linker, facilitates PROTAC synthesis[1].

2,3-dihydroxyundecanedioic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-hydroxyundecanedioic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

MS 39 is a potent Proteolysis Targeting Chimera (PROTAC) designed to degrade the Epidermal Growth Factor Receptor (EGFR). The molecule is composed of three structural motifs: an EGFR target ligand (red part), a VHL E3 ligase ligand (S,R,S)-AHPC (blue part), and an undecanedioic acid linker (black part). By facilitating the formation of a ternary complex between EGFR and the VHL E3 ubiquitin ligase, MS 39 triggers the polyubiquitination and subsequent proteasomal degradation of the receptor. MS 39 effectively reduces EGFR protein levels and inhibits downstream oncogenic signaling in HCC-827 and H3255 cell lines, leading to significant suppression of H3255 cancer cell proliferation.