sulfasalazine

Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative with affinity for elastin-containing connective tissues and formulated as a prodrug. Sulfasalazine induces iron death and inhibits NF-κB, TGF-β and COX-2.

Sulfapyridine (2-Sulfapyridine) is a short-acting sulfonamide antibiotic and by-product of the non-steroidal anti-inflammatory drug sulfasalazine.

Sulfasalazine-D4 is a deuterated compound of Sulfasalazine. Sulfasalazine (T0907) has a CAS number of 599-79-1. Sulfasalazine (T0907) is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug

GPX4-AUTAC is an autophagy-mediated degrader (AUTAC) targeting GPX4. It consists of the inhibitor ML162-yne, a degradation tag FBnG, and a glycol linker. GPX4-AUTAC facilitates the ubiquitination of GPX4 by the E3 ligase TRAF6 and enhances its interaction with GPX4 and p62, leading to selective autophagy-dependent degradation of GPX4. This compound significantly induces ferroptosis and demonstrates potent anticancer activity in breast cancer cells, patient-derived organoids (PDOs), and MDA-MB-231 tumor xenograft mouse models. It shows strong synergy when used in combination with Sulfasalazine (SAS) or chemotherapy drugs (Paclitaxel or Cisplatin).

Olsalazine-13C6 is intended for use as an internal standard for the quantification of olsalazine by GC- or LC-MS. Olsalazine (T20615) is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA.1

Anti-Mouse IL-1b Antibody (B122) is a monoclonal antibody inhibitor targeting mouse IL-1β. It blocks IL-1β signaling, thereby reducing monocyte infiltration and alleviating T cell exhaustion, making it useful for studying cancer and cardiovascular diseases. When combined with sulfasalazine, Anti-Mouse IL-1β Antibody (B122) enhances ferroptosis and reactive oxygen species (ROS) levels.

Sulfapyridine (Standard) is the standard substance of Sulfapyridine, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Sulfapyridine (2-Sulfapyridine) is a short-acting sulfonamide antibiotic and by-product of the non-steroidal anti-inflammatory drug sulfasalazine.