indomethacin-d-4

Indomethacin-D4 is a deuterium labeled Indomethacin. Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells.

Indomethacin-d4Methyl Ester is the deuterated form of Indomethacin. Indomethacin (Indometacin) serves as a potent, non-selective inhibitor of COX-1 and COX-2 that can cross the blood-brain barrier, with IC50 values of 18 nM for COX-1 and 26 nM for COX-2 in CHO cells. It disrupts autophagic flux by interfering with the normal function of lysosomes.