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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2125 | Trametinib | GSK1120212,JTP-74057 | Apoptosis , MEK , Autophagy |
Trametinib (GSK1120212) is a MEK inhibitor that inhibits MEK1 and MEK2 (IC50=0.7/0.9 nM) with ATP non-competitive and oral activity. Trametinib activates autophagy and induces apoptosis. | |||
T5857 | Trametinib (DMSO solvate) | Trametinib DMSO solvate,GSK-1120212 (DMSO solvate),Trametinib dimethyl sulfoxide,JTP-74057 (DMSO solvate) | Apoptosis , MEK |
Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 :2 nM) | |||
T73141 | GSK1790627 | ||
GSK1790627, the N-deacetylated metabolite of Trametinib, represents an orally active MEK inhibitor that promotes autophagy and triggers apoptosis [1]. | |||
T75110 | Trametiglue | ||
Trametiglue, a Trametinib derivative, exhibits exceptional potency and selectivity in targeting KSR-MEK and RAF-MEK through distinctive interfacial binding interactions [1]. | |||
T83865 | HP661 | ||
HP661, a selective inhibitor of mitochondrial complex I (NADH dehydrogenase), impedes complex I activity by 77.6% at 1 µM, demonstrating lesser inhibition towards complex III (28.1%) and no inhibitory effects on complexe... |