T7518

Deoxycytidine triphosphate trisodium salt (2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODI) contributes to antibiotic lethality in stationary-phase mycobacteria.

Antifungal Agent 57 (Compound A19) demonstrates potent efficacy against Fluconazole-resistant strains, outperforming Miconazole. It effectively inhibits Candida albicans strains, exhibiting minimum inhibitory concentrations (MIC) ranging from 0.5 to 2 μg/mL [1].

Antifungal agent 58 (compound A21) demonstrates high potency against Fluconazole-resistant strains and surpasses Miconazole in effectiveness, inhibiting Candida albicans with minimum inhibitory concentration (MIC) values ranging from 0.06 to 8 μg/mL [1].

G13KS is a deubiquitinase UCHL1 ligand and inhibitor that reduces levels of monoubiquitin in human glioblastoma cells by inhibiting both recombinant and cellular UCHL1 [1].

3,5'-Bis(O-t-butyldimethylsilyl)-2'-O-methyl-5-methyl cytidine, a cytidine analog, inhibits DNA methyltransferases (e.g., Zebularine) and exhibits potential anti-metabolic and anti-tumor activities [1].

6-Amino-4-methoxy-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine, a pyrimidine nucleoside analog, exhibits a broad spectrum of biochemical and anticancer activities, including inhibition of DNA and RNA synthesis, antiviral effects, and immunomodulatory effects [1].

5'-O-Benzoyl-3'-O-(4-methoxybenzyl)-2'-O,4'-C-methyleneuridine is a purine nucleoside analog with broad antitumor activity, primarily targeting indolent lymphoid malignancies. Its anticancer mechanisms include inhibiting DNA synthesis and inducing apoptosis, among others [1].

2'-Deoxy-2'-fluorouridine 5'-monophosphate triethyl ammonium, a purine nucleoside analog, demonstrates significant antitumor effects against indolent lymphoid malignancies by primarily inhibiting DNA synthesis and inducing apoptosis [1].

5-Caroxy uracil-1-yl acetic acid benzyl ester, a purine nucleoside analog, exhibits broad antitumor activity primarily against indolent lymphoid malignancies. Its anticancer mechanisms include inhibiting DNA synthesis and inducing apoptosis, among other pathways [1].