T6190

Telaprevir (Incivek) (VX-950) is an effective inhibitor of HCV NS3-4A serine protease (IC50: 0.35 μM).

σ 1 Receptor/ μ Opioid receiver modulator 1 (Compound 44) is an effective σ 1 receptor antagonist (Ki=1.86 nM) and μ Opioid receptor agonists (Ki=2.1 nM). Opioid receptor modulator 1 shows potent analgesic activity, and can be used for the research of neuropathic pain.

Anticancer agent 69 (Compound 34) is an effective selective anticancer agent with selective inhibition on human prostate cancer cell line PC3 (IC50=26 nM). Anticancer agent 69 can increase ROS level and down-regulate EGFR, thus inducing apoptosis.

(R)-ONO-2952 is the R-enantiomer of ONO-2952. ONO-2952 is selective and oral effective TSPO antagonist, with Kis of 0.330-9.30 nM inhibiting rat and human TSPO.

HSP90-IN-14 (compound 4) is an effective Hsp90 inhibitor (Kd=0.26 μM). In MDCK cells, HSP90-IN-14 demonstrated anti-influenza virus activity with EC50 values of 2.6 μM against influenza A/H3N2, 3.9 μM against A/H1N1, and 17 μM against the B virus.

RKI 1447 dihydrochloride is an effective and selective ROCK inhibitor (ROCK1 IC50=14.5 nM, ROCK2 IC50=6.2 nM). RKI 1447 dihydrochloride can inhibit the growth of colorectal cancer cells and promote cell apoptosis.

POP-IN-1 (Compound 12h) is an effective POP inhibitor (Ki=0.009 μM) with research potential in neurodegenerative diseases and cancer progression.

Estrogen Receptor Antagonist 7 (Compound 13) is a potent antagonist of estrogen receptors (ER), demonstrating antiproliferative effects against breast and ovarian cancer cells, along with anticancer and anti-uterotrophic activities [1].