T1551

Tegaserod maleate (SDZ-HTF-919) is a 5-HT4 agonist manufactured by Novartis for managing irritable bowel syndrome and constipation. It was the only drug approved by the United States Food and Drug Administration for relieving abdominal discomfort, bloating, and constipation associated with irritable bowel syndrome. On March 30, 2007, the FDA requested that Novartis withdraw Zelnorm from the market due to alleged increased risks of heart attack or stroke associated with its use.

Hydroxy-PEG1-acid is a non-cleavable 1-unit polyethylene glycol (PEG) linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Hydroxy-PEG1-C2-methyl ester, a polyethylene glycol (PEG) derived linker, is widely used in the production of PROTACs (proteolysis targeting chimeras). [1]

Hydroxy-PEG1-(CH2)2-Boc is a polyethylene glycol (PEG)-based linker utilized in the synthesis of proteolysis-targeting chimeric molecules (PROTACs)[1].

Hydroxy-PEG1-CH2-Boc is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Hydroxy-PEG10-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG10-Boc can be conjugated to Paclitaxel or docetaxel [2].

Hydroxy-PEG2-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Hydroxy-PEG2-C2-methyl ester, a polyethylene glycol (PEG)-based linker, is commonly utilized for the synthesis of proteolysis targeting chimeras (PROTACs) [1].

Hydroxy-PEG2-C2-PFP ester, a PEG/Alkyl/ether-based PROteolysis TArgeting Chimeric (PROTAC) linker, is suitable for the synthesis of PROTACs.

Hydroxy-PEG2-C2-sulfonic acid, a PEG-based linker for PROTACs, connects two essential ligands critical for forming PROTAC molecules, thereby enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Hydroxy-PEG2-(CH2)2-Boc is an uncleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs).