T1448

Dasatinib (BMS-354825) is an orally active, ATP-competitive tyrosine kinase inhibitor that targets Src and Bcr-Abl (Ki=16/30 pM), with antitumor activity, used in the treatment of leukemia and lymphoma.

Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib monohydrate binds to and inhibits the growth-promoting activities of these kinases. Apparently, because of its less stringent binding affinity for the BCR-ABL kinase, Dasatinib monohydrate has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations.

Azido-PEG8-PFP ester is a PEG-based linker used in PROTACs to connect two essential ligands, facilitating the formation of PROTAC molecules. It enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Azido-PEG9-acid, a non-cleavable 9-unit PEG ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs).

Azido-PEG9-amine, a non-cleavable 9-unit PEG ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs)[1].

Azido-PEG9-Boc is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Azidoethyl-SS-ethylamine is a cleavable linker compound used in the synthesis of antibody-drug conjugates (ADCs)[1].

Azidoethyl-SS-ethylazide is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Azidoethyl-SS-PEG2-Boc is a PEG-based linker for PROTACs that joins two essential ligands, facilitating selective protein degradation by the ubiquitin-proteasome system within cells.

AZM475271 is a potent and selective inhibitor of Src kinase (IC50: 5 nM).

AZT-PMPA, an aryl phosphate derivative of AZT and a nucleoside analogue, demonstrates anti-HIV activity[1]. As a nucleoside reverse transcriptase inhibitor (NRTI), AZT-PMPA targets HIV infection effectively[2].

Azvudine (FNC) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine inhibits NRTI-resistant viral strains. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).

Dasatinib-D8 is deuterium-labeled dasatinib. Dasatinib (T1448) is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.