T0334

Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidinedione insulin sensitizer.

Rosiglitazone-D3 is the deuterated form of Rosiglitazone. Rosiglitazone (T0334) (BRL 49653) is a thiazolidinedione class insulin sensitizer and a selective, orally active PPARγ agonist. It exhibits EC50 values of 30 nM for PPARγ1, 100 nM for PPARγ2, and 60 nM for PPARγ, with a binding affinity (Kd) to PPARγ of approximately 40 nM. Additionally, Rosiglitazone (T0334) acts as an activator of TRPC5 (EC50 ≈ 30 μM) and an inhibitor of TRPM3.