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Search Result

Search Results for " pak "

Targets

PAK

22

Compounds

2

Natural Products

7

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T30708 PAK 4437
Carbamic acid, (3-(hexyloxy)phenyl)-, 1-butyl-4-piperidinyl ester, monohydrochloride (9CI) is a bioactive chemical.
T27164 DHP-218 PAK-9,PAK9,PAK 9,DHP218
DHP-218 is a calcium channel antagonist. DHP-218 inhibits Calcium-induced contraction of the rat aorta in high K+ solution with the pA2 value of 9.11. The IC50 value for the inhibitory effects of DHP-218 in high K+-induc...
T16367 NVS-PAK1-1 PAK
NVS-PAK1-1 is an effective and selective allosteric PAK1 inhibitor (IC50: 5 nM).
T6839 FRAX1036 PAK
FRAX-1036 is a effective and selective PAK1 inhibitor.
T16429 GNE 2861 PAK
GNE 2861 inhibits PAK4, PAK5, and PAK6 (IC50s: 7.5, 36, 126 nM, respectively). GNE 2861 is a PAK inhibitor that shows group II selectivity.
T6840 FRAX486 PAK
FRAX486 is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively.
T6014 FRAX597 PAK
FRAX597 is an effective, ATP-competitive inhibitor of group I PAKs, and for PAK1(IC50=8 nM), PAK2(IC50=13 nM), and PAK3 (IC50=19 nM).
T11342L G-5555 PAK
G-5555 is a potent inhibitor of p21-activated kinase 1 (PAK1) (Kis: 3.7 nM and 11 nM for PAK1 and PAK2, respectively).
T6546 IPA-3 IPA3,IPA 3 PAK
IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6).
T6626 PF-3758309 PF-309,PF-03758309,PF 3758309 Apoptosis , PAK
PF-3758309 (PF-03758309) (IC50=1.3 nM), a pyrrolopyrazole inhibitor of PAK4, has effective ATP-competition.
T11826 LCH-7749944 GNF-PF-2356 Apoptosis , PAK
LCH-7749944 (GNF-PF-2356) effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis. LCH-7749944 is a potent PAK4 inhibitor w...
T2539 Fingolimod hydrochloride Fingolimod (FTY720) HCl,FTY720 TRP/TRPV Channel , S1P Receptor , PAK , LPL Receptor
Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
T41166 NVS PAK1 C
NVS PAK1 C is a negative control of NVS PAK1 1, a potent and selective PAK1 inhibitor.
T4230 PF-3758309 hydrochloride PF-03758309 hydrochloride Apoptosis , PAK
PF-3758309 hydrochloride (PF-03758309 hydrochloride) , is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 hyd...
T35928 NVS-PAK1-C NVS-PAK1-C
NVS-PAK1-1 is a potent allosteric inhibitor of PAK1 with an IC 50 of 5 nM for dephosphorylated PAK1 and 6 nM for phosphorylated PAK1 as assessed. Inhibition is ATP-competitive, most likely due to indirect competition due...
T81569 PAK4-IN-3 PAK
PAK4-IN-3 (compound 27e) is a PAK4 inhibitor exhibiting an IC50 of 10 nM and demonstrates antiproliferative effects on A549 cells with an IC50 of 0.61μM. It also induces concentration-dependent apoptosis in A549 cells an...
T63031 PAK1-IN-1
PAK1-IN-1 is a selective and potent inhibitor of PAK1 (IC50: 9.8 nM). PAK1-IN-1 inhibits PAK1-associated tumour cell migration and invasion in a dose-dependent manner.
T63934 PAK4-IN-1
PAK4-IN-1 is a selective, potent, orally active PAK4 inhibitor that is stable under both acidic and neutral conditions.PAK4-IN-1 exhibits good anti-tumour effects in vivo.
T61299 PAK4-IN-2
PAK4-IN-2 is an exceptionally effective inhibitor of PAK4, exhibiting an IC 50 value of 2.7 nM. This compound is capable of arresting MV4-11 cells at the G0/G1 phase and inducing cell apoptosis. It holds significant pote...
T6840L FRAX486 HCL(1232030-35-1 free base) PAK
FRAX486 HCL is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively.
T24078 G-9791 G9791
G-9791 is an effective and selective inhibitor of group-I PAK.
T82385 FMF-06-098-1 PROTACs
FMF-06-098-1 is a multitargeted depressant capable of promoting the degradation of a wide array of kinases, including AAK1, ABL2, AURKA, AURKB, BUB1B, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDK6, CDK7, CDK9, CHEK1, CSNK1D...
Cat No. Product Name Synonyms Targets
T0646 5-Aminosalicylic Acid Mesalazine,5-ASA,Mesalamine NF-κB , Lipoxygenase , COX , Glutathione Peroxidase , Endogenous Metabolite , PAK , PPAR
5-Aminosalicylic Acid (5-ASA) is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE.
T7939 Fingolimod FTY-720A,FTY-720 S1P Receptor , PAK , LPL Receptor
Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).

Natural Products

5-Aminosalicylic Acid
T0646
Synonym: Mesalazine,5-ASA,Mesalamine
Target: NF-κB, Lipoxygenase, COX, Glutathione Peroxidase, Endogenous Metabolite, PAK, PPAR
Fingolimod
T7939
Synonym: FTY-720A,FTY-720
Target: S1P Receptor, PAK, LPL Receptor

Recombinant Proteins

Species：
Human (6)
Vespa mandarinia (1)
Expression System：
Baculovirus-Insect Cells (4)
E. coli (2)
Baculovirus (1)
Tag：
GST (2)
His (1)
His,GST (1)
N-terminal 6xHis-KSI-tagged (1)
N-terminal 6xHis-SUMO-tagged (1)
N-terminal 6xHis-tagged (1)
Cat No. Product Name Species Expression System
TMPY-04397 PAK-3 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
PAK3 is a member of PAK proteins, a family of serine/threonine p21-activating kinases, serve as effectors of small Rho GTPases Cdc42 and RAC and have been implicated in a wide range of biological activities. There are si...
TMPH-02091 PAK1 Protein, Human, Recombinant (His & SUMO) Human E. coli
PAK1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPH-03701 Vespakinin-M Protein, Vespa mandarinia, Recombinant (His & KSI) Vespa mandarinia E. coli
Vespakinin-M Protein, Vespa mandarinia, Recombinant (His & KSI) is expressed in E. coli.
TMPH-02092 PAK5 Protein, Human, Recombinant (His) Human Baculovirus
PAK5 Protein, Human, Recombinant (His) is expressed in Baculovirus.
TMPY-04559 CDC42BPB Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
CDC42BPB is a member of the serine / threonine protein kinase family that contains a Cdc42 / Rsc-binding p21 binding domain similar to that of PAK kinase. The kinase domain of this protein is related to the myotonic dyst...
TMPY-01187 Rac1 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
RAC1 is a GTPase that belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal re...
TMPY-04460 OXSR1 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
Oxidative stress-responsive 1 protein (OXSR1), also known as Serine/threonine-protein kinase OSR1, is a member of the Ser/Thr protein kinase family of proteins. OXSR1 regulates downstream kinases in response to environme...
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