Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Filter
Applied FilterClear all
TargetMol | Tags By Target
  • ASK
    (5)
  • Antibiotic
    (1)
  • Apoptosis
    (5)
  • DNA Alkylation
    (1)
  • FLT
    (1)
  • MAPK
    (11)
  • MEK
    (1)
  • PDGFR
    (1)
  • Src
    (1)
  • Others
    (6)
Filter
Search Result
Results for "

MAP3K

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    17
    TargetMol | Activity
  • PROTAC Products
    1
    TargetMol | inventory
  • Natural Products
    2
    TargetMol | natural
  • Recombinant Protein
    3
    TargetMol | composition
K-Ras G12C-IN-3
T117371629268-19-4
Heterocyclic compounds as covalent inhibitors of G12C mutant K-Ras protein useful for treating cancers.K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.
  • $347
6-8 weeks
Size
QTY
K 259-3
T32348127172-90-1
K 259-3, a methyl ester of K 259-2, is an inhibitor of calmodulin-dependent cyclic nucleotide phosphodiesterase.
  • $1,520
Backorder
Size
QTY
Cathepsin K inhibitor 3
T722961694638-70-4
Cathepsin K Inhibitor 3, exhibiting an IC50 value of 0.5 nM, is a highly selective inhibitor of cathepsin K, featuring a favorable pharmacokinetic profile. It holds potential for use in studies of osteoarthritis (OA).
  • $2,120
8-10 weeks
Size
QTY
K-Ras ligand-Linker Conjugate 3
T180562378261-87-9
K-Ras ligand-Linker Conjugate 3 (Compound 001371) is a chemical compound comprising a ligand for the K-Ras recruiting moiety and a PROTAC linker, responsible for recruiting E3 ligases (e.g., VHL, CRBN, MDM2, and IAP). This compound is essential for synthesizing PROTAC K-Ras Degrader-1, a potent degrader with a degradation efficacy of ≥70% in SW1573 cells[1].
  • Inquiry Price
Size
QTY
TC ASK 10
T130991005775-56-3In house
TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1)(IC50 of 14 nM).
  • $29
In Stock
Size
QTY
TargetMol | Inhibitor Sale
MAP3K5-IN-1
TN76022226941-29-1
Compound 7, also known as 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine, serves as an inhibitor of protein kinases, displaying IC50 values of 0.092 μM for PKC-α, 0.26 μM for ROCK, and 0.77 μM for ASK1. Additionally, this compound exhibits significant cytotoxicity towards PC-3 cancer cells, with an IC50 of 0.16 μM [1].
  • Inquiry Price
Inquiry
Size
QTY
MAP3K14-IN-173
T698942113617-02-8
MAP3K14-IN-173 is a potent MAP3K14 kinase inhibitor.
  • $2,870
10-14 weeks
Size
QTY
Takinib
T42641111556-37-6
Takinib (EDHS-206) is a specific and effective TAK1 inhibitor(IC50= 9.5 nM).
  • $66
In Stock
Size
QTY
TargetMol | Citations Cited
Selonsertib
T33501448428-04-3
Selonsertib (GS-4997) is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.
  • $33
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
NQDI-1
T3101175026-96-7
NQDI-1 (NQDI 1) is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50/Ki: 3 μM/500 nM).
  • $39
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
NG25
T56431315355-93-1
NG25 is a potent dual inhibitor of TAK1 and MAP4K2, with IC50s of 149 nM and 21.7 nM, respectively.
  • $79
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
GNE-3511
T37071496581-76-0
GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.
  • $45
In Stock
Size
QTY
TargetMol | Inhibitor Sale
HS220
T600111570374-32-1
HS220 is an inhibitor of TAK1 which plays a key role in the signaling pathways of inflammation and cell survival.
  • $75
In Stock
Size
QTY
TargetMol | Inhibitor Sale
ASK1-IN-2
T93772541792-70-3
ASK1-IN-2 is a potent, orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. It has potential therapeutic applications for ulcerative colitis[1].
  • $68
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TAO Kinase inhibitor 1
T16987850467-66-2
TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death. TAO Kinase inhibitor 1 is a selective and ATP-competitive thousand-and-one amino acid kinases inhibitor (IC50s: 11 to 15 nM for TAOK1 and 2, respectively).
  • $64
In Stock
Size
QTY
TargetMol | Inhibitor Sale
GS-444217
T51901262041-49-5
GS-444217 is a selective ATP-competitive inhibitor of apoptosis signal-regulating kinase 1 (ASK1, IC50: 2.87 nM).
  • $40
In Stock
Size
QTY
TargetMol | Inhibitor Sale
5Z-7-Oxozeaenol
T14055253863-19-3
5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK1 and low activity against MEK1 with IC50 of 411 nM, it is also an inhibitor of VEGF-R2 with IC50 of 52 nM.
  • $215
In Stock
Size
QTY