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Search Result

Search Results for " atp-sensitive "

Targets

Potassium Channel

38

Compounds

3

Natural Products

3

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T15385 Glibornuride Potassium Channel
Glibornuride is an ATP-sensitive K+ channels (KATP channel) blocker ( pKi: 5.75). It is an antidiabetic agent.
T9714 Atpenin A5 Potassium Channel
Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM). Atpenin A5 is also an effective mKATP channel agonist and cardioprotective agent[1].
T1603 Glipizide CP 28720,K 4024 Potassium Channel , PPAR , ABC
Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
T1634 Glibenclamide Glyburide Potassium Channel , Mitochondrial Metabolism , CFTR , P-gp , Autophagy
Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T1101 Minocycline hydrochloride Minocycline HCl HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic
Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochlor...
TQ0150 Levcromakalim (-)-Cromakalim,BRL 38227 Potassium Channel
Levcromakalim (BRL 38227) is an activator of the ATP-sensitive K+ channel.
T10566 BMS-191095 Potassium Channel
BMS-191095 is mitochondrial ATP-sensitive potassium (mitoKATP) channel activator.
T23563 ZM 226600 Potassium Channel
ZM 226600 is an ATP-sensitive potassium channel opener with an EC50 value of 500 nM. ZM226600 has an inhibitory effect on spontaneous bladder activity.
T90604 PCO 400
PCO 400 is an analog of comakalim that acts as a selective and potent ATP-sensitive K+ channel opener.
T16420 P-1075 Potassium Channel
P-1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species causing cardioprotection of rabbit hearts. P-1075 is an effective activator of sulfonylurea receptor 2-associated ATP-sensitive potassium c...
T21478 Cromakalim BRL-34915,BRL 34915,(±)-Cromakalim,BRL34915
Cromakalim, a potassium channel-opening vasodilator, acts on ATP-sensitive potassium channels and so causes membrane hyperpolarization, it can be used to treat hypertension as it will relax vascular smooth muscle to lowe...
T6587 Mitiglinide Calcium KAD-1229,S21403 ATPase , Potassium Channel
Mitiglinide Calcium (KAD-1229) is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.
T29457L 5-Hydroxydecanoate sodium Potassium Channel
5-Hydroxydecanoate sodium is a selective ATP-sensitive K+ (KATP) channel blocker with IC50 of about 30 μM. 5-Hydroxydecanoate sodium is a substrate for mitochondrial outer membrane acyl-CoA synthetase with antioxidant p...
T26086L 1-((3R,4S)-3-hydroxy-2,2-dimethyl-6-(phenylsulfonyl)chroman-4-yl)pyrrolidin-2-one Others
1-((3R,4S)-3-hydroxy-2,2-dimethyl-6-(phenylsulfonyl)chroman-4-yl)pyrrolidin-2-one is an isomer of Rilmakalim, a potassium channel opener (PCO), which can activate ATP-sensitive K+ channels in the heart or other tissues
T1530 Mitiglinide calcium hydrate KAD-1229 calcium hydrate,Mitiglinide calcium,S-21403 calcium hydrate Potassium Channel
Mitiglinide calcium hydrate (S-21403 calcium hydrate) is a drug for the treatment of type 2 diabetes. Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) K(ATP) channels in pancreatic ...
T27624 Iptakalim Hydrochloride Potassium Channel , AChR
Iptakalim, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine receptor (nAChR) antagonist. Iptakalim is also a K(ir) 6.1/SUR2...
T1781 GW9508 GW 9508 GPR , Potassium Channel
GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner.
T35107 Way 120491 Way120491,Way-120,491,Way-120491,Celikalim
Way 120491 activates ATP-sensitive potassium channels.
T71929 Clamikalant
Clamikalant inhibits ATP-sensitive potassium channel.
T30487 BMS 180448 BMS-180448,BMS180448
BMS 180448 is a prototype mitochondrial ATP-sensitive K+ (Mitok (ATP)) channel opener with cardioprotective and vasodilating properties.
T70801 ZM-181037
ZM-181037 is an ATP-sensitive potassium channel-blocker and a eukalemic diuretic.
T17268 Y-26763 Others
Y-26763 is a K+ channel opener and active metabolite of Y-27152. This is an ATP-sensitive K+ (KATP) channel activator.
T28977 Tilisolol HCl Tilisolol, trade name Selecal,N 696,N-696,N696
Tilisolol is a nonselective blocker of beta-adrenergic. Tilisolol hydrochloride dilates coronary arteries through an ATP-sensitive K(+)-channel opening mechanism in dogs.
T24435 MCC-134 MCC 134,MCC134
MCC-134 is an inverse agonist for the pancreatic-type ATP-sensitive K(+) channel. It also used as a vascular relaxing agent.
T25102 Aprikalim RP52891,RP-52891,RP 52891
Aprikalim is a specific and selective ATP-sensitive K+ (KATP) channel opener. Aprikalim affords cardioprotection and at higher doses also cause peripheral or coronary vasodilatation.
T11243 Ethyl tosylcarbamate Others
Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877).
T68745 U 56324
U-56324 is a hypoglycemic agent derived from nicotinic acid. It was found to inhibit the activity of ATP-sensitive potassium channels in excised patches from mouse pancreatic B-cells.
T68602 AZ-DF 265
AZ-DF 265 is a hypoglycaemic drug which stimulates insulin release. AZ-DF-265 inhibits ATP-sensitive potassium channels and displaces [3H]-glibenclamide from the sulphonylurea receptor.
T75084 Foslevcromakalim
Foslevcromakalim (QLS-101), an ATP-sensitive potassium channel opener, serves as a proagent for ocular hypotensive effects [1] [2].
T63330 Clamikalant sodium
Clamikalant sodium is a non-selective, ATP-sensitive potassium (KATP) channel blocker that can be used to study cardiac arrhythmias.
T25739 Linogliride McN-3935,McN3935,McN 3935,Linogliridum,Linoglirida
Linogliride is a guanidine-based inhibitor of insulin secretion and a structural analog of pirogliride with hypoglycemic activity. It blocks ATP-sensitive potassium channels in the pancreatic beta cell membrane, thereby ...
T11002 Desethylamiodarone hydrochloride N-desethylamiodarone hydrochloride,LB 33020 hydrochloride Others
Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is formed by the CYP3A isozyme. Amiodarone is an antiarrhythmic drug that inhibits ATP-sensitive potassium channels with an IC50 of 19.1 μM. It is the...
T21431 Mitiglinide
Mitiglinide (KAD-1229) is an insulinotropic agent that is an ATP-sensitive K + (K ATP ) channel antagonist. Mitiglinide is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell K ATP channel). Mitiglinide ...
T25739L Linogliride fumarate McN 3935,McN-3935,McN3935
Linogliride fumarate is the fumarate salt of Linogliride. Linogliride is a guanidine-based inhibitor of insulin secretion and a structural analog of pirogliride with hypoglycemic activity. It blocks ATP-sensitive potassi...
T11038 Dibutyryl-cGMP sodium Bt2cGMP sodium Others
Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analog. Dibutyryl-cGMP sodium preferentially activates cGMP-dependent protein kinase (PKG). Dibutyryl-cGMP sodium inhibits [3H]-arachidonic acid release in ...
T71402 Nicorandil-d4
Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir...
T71981 Gliclazide-d4
Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. ...
T36740 Guanosine 5’-diphosphate (sodium salt hydrate)
Guanosine 5’-diphosphate (GDP) is a purine nucleotide and biosynthetic precursor of guanosine 5’-triphosphate .1It has been used to study the conformations of GTPases.2GDP (100 μM) activates sulfonylurea receptor 2B (SUR...

Compounds

Glibornuride
T15385
Synonym:
Target: Potassium Channel
Atpenin A5
T9714
Synonym:
Target: Potassium Channel
Glipizide
T1603
Synonym: CP 28720,K 4024
Target: Potassium Channel, PPAR, ABC
Glibenclamide
T1634
Synonym: Glyburide
Target: Potassium Channel, Mitochondrial Metabolism, CFTR, P-gp, Autophagy
Minocycline hydrochloride
T1101
Synonym: Minocycline HCl
Target: HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic
Levcromakalim
TQ0150
Synonym: (-)-Cromakalim,BRL 38227
Target: Potassium Channel
BMS-191095
T10566
Synonym:
Target: Potassium Channel
ZM 226600
T23563
Synonym:
Target: Potassium Channel
PCO 400
T90604
Synonym:
Target:
P-1075
T16420
Synonym:
Target: Potassium Channel
Cromakalim
T21478
Synonym: BRL-34915,BRL 34915,(±)-Cromakalim,BRL34915
Target:
Mitiglinide Calcium
T6587
Synonym: KAD-1229,S21403
Target: ATPase, Potassium Channel
5-Hydroxydecanoate sodium
T29457L
Synonym:
Target: Potassium Channel
1-((3R,4S)-3-hydroxy-2,2-dimethyl-6-(phenylsulfonyl)chroman-4-yl)pyrrolidin-2-one
T26086L
Synonym:
Target: Others
Mitiglinide calcium hydrate
T1530
Synonym: KAD-1229 calcium hydrate,Mitiglinide calcium,S-21403 calcium hydrate
Target: Potassium Channel
Iptakalim Hydrochloride
T27624
Synonym:
Target: Potassium Channel, AChR
GW9508
T1781
Synonym: GW 9508
Target: GPR, Potassium Channel
Way 120491
T35107
Synonym: Way120491,Way-120,491,Way-120491,Celikalim
Target:
Clamikalant
T71929
Synonym:
Target:
BMS 180448
T30487
Synonym: BMS-180448,BMS180448
Target:
ZM-181037
T70801
Synonym:
Target:
Y-26763
T17268
Synonym:
Target: Others
Tilisolol HCl
T28977
Synonym: Tilisolol, trade name Selecal,N 696,N-696,N696
Target:
MCC-134
T24435
Synonym: MCC 134,MCC134
Target:
Aprikalim
T25102
Synonym: RP52891,RP-52891,RP 52891
Target:
Ethyl tosylcarbamate
T11243
Synonym:
Target: Others
U 56324
T68745
Synonym:
Target:
AZ-DF 265
T68602
Synonym:
Target:
Foslevcromakalim
T75084
Synonym:
Target:
Clamikalant sodium
T63330
Synonym:
Target:
Linogliride
T25739
Synonym: McN-3935,McN3935,McN 3935,Linogliridum,Linoglirida
Target:
Desethylamiodarone hydrochloride
T11002
Synonym: N-desethylamiodarone hydrochloride,LB 33020 hydrochloride
Target: Others
Mitiglinide
T21431
Synonym:
Target:
Linogliride fumarate
T25739L
Synonym: McN 3935,McN-3935,McN3935
Target:
Dibutyryl-cGMP sodium
T11038
Synonym: Bt2cGMP sodium
Target: Others
Nicorandil-d4
T71402
Synonym:
Target:
Gliclazide-d4
T71981
Synonym:
Target:
Guanosine 5’-diphosphate (sodium salt hydrate)
T36740
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T3S0870 Paederosidic acid methyl ester ATPase , Potassium Channel , NO Synthase
Paederosidic acid methyl ester has antinociception, is possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels.
T3929 Kaurenoic acid Kauren-19-Oic Acid,kaurenoate,kaur-16-en-18-oic acid Others
Kaurenoic acid (kaurenoate) has anti-inflammatory potential in acetic acid-induced colitis, decreases in MDA level. Kaurenoic acid exerts a uterine relaxant effect acting principally through calcium blockade and in part,...
TN4322 Isopulegol ATPase , Potassium Channel , GABA Receptor
Isopulegol presents depressant- and anxiolytic-like effects, it also has anticonvulsant and bioprotective effects against PTZ-induced convulsions are possibly related to positive modulation of benzodiazepine-sensitive GA...

Natural Products

Paederosidic acid methyl ester
T3S0870
Synonym:
Target: ATPase, Potassium Channel, NO Synthase
Kaurenoic acid
T3929
Synonym: Kauren-19-Oic Acid,kaurenoate,kaur-16-en-18-oic acid
Target: Others
Isopulegol
TN4322
Synonym:
Target: ATPase, Potassium Channel, GABA Receptor

Recombinant Proteins

Species：
Mouse (2)
Human (1)
Expression System：
Baculovirus (1)
Baculovirus-Insect Cells (1)
E. coli (1)
Tag：
N-terminal 6xHis-tagged (2)
His,GST (1)
Cat No. Product Name Species Expression System
TMPY-02840 Ubiquitin Activating Enzyme E1/UBA1 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
UBE1, also known as UBA1, belongs to the ubiquitin-activating E1 family. UBE1 gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cl...
TMPH-02479 PRKAA1 Protein, Mouse, Recombinant (E. coli, His) Mouse E. coli
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activat...
TMPH-02478 PRKAA1 Protein, Mouse, Recombinant (His) Mouse Baculovirus
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activat...
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