TQ0003L |
740 Y-P(TFA)(1236188-16-1 free base)
|
TQ0003L
|
98%
|
|
740 Y-P(TFA)(1236188-16-1 free base) (740YPDGFR(TFA)) is a potent and cell-permeable activator of PI3K.
|
T72374 |
PI3K/mTOR Inhibitor-12
|
2891692-83-2
|
98%
|
|
PI3K/mTOR Inhibitor-12, a potent and selective orally active inhibitor, exhibits IC50 values of 0.06 nM for PI3Kα and 3.12 nM for mTOR, indicating significant an...
|
T72713 |
PI3K/VEGFR2-IN-1
|
2851067-08-6
|
98%
|
|
PI3K/VEGFR2-IN-1 is a potent dual inhibitor targeting both PI3K and VEGFR2 with IC50 values of 2.21 μM for PI3K and 68 μM for VEGFR2, respectively. This compound...
|
T12467 |
PI4KIII beta inhibitor 3
|
1245319-54-3
|
98%
|
|
PI4KIII beta inhibitor 3 is a novel and high effective inhibitor of PI4KIIIβ (IC50 of 5.7 nM).
|
T74782 |
CXJ-2
|
2919976-92-2
|
98%
|
|
CXJ-2, a cyclic peptide, demonstrates moderate affinity for elastin-derived peptides (EDPs) and exhibits potent inhibition of the PI3K/ERK pathway, alongside sig...
|
T11610 |
Idelalisib D5
|
1830330-31-8
|
98%
|
|
Idelalisib D5, a version of Idelalisib marked with deuterium, is an orally bioavailable and highly selective inhibitor of p110δ.
|
TN5201 |
Uncarinic acid E
|
277751-61-8
|
98%
|
|
Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resul...
|
T16908 |
Sonolisib
|
502632-66-8
|
98%
|
|
Sonolisib is an irreversible and pan-isoform inhibitor of PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)).
|
T12458 |
PI3K-IN-9
|
2360875-63-2
|
98%
|
|
PI3K-IN-9 is a potent and selective inhibitor of PI3Kδ(IC50 of 8.9 nM).
|
T17066 |
Umbralisib hydrochloride
|
1532533-78-0
|
98%
|
|
Umbralisib hydrochloride is a novel PI3Kδ inhibitor (IC50 and EC50 of 22.2 nM and 24.3 nM, respectively). Umbralisib hydrochloride is also active against CK1ε (E...
|
TN5050 |
Sprengerinin C
|
88861-91-0
|
98%
|
|
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can st...
|
T10660L2 |
CAL-130 Racemate
|
474012-90-3
|
98%
|
|
CAL-130 Racemate is the racemate of CAL-130. CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).
|
T77629 |
FD274
|
2641899-38-7
|
98%
|
|
FD274 is a potent dual PI3K/mTOR inhibitor with inhibitory effects on PI3Kα/β/γ/δ and mTOR, with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM, respec...
|
T15800 |
LY117018
|
63676-25-5
|
98%
|
|
LY117018 shows antiproliferative effects on breast cancer cell lines. LY117018 is a Raloxifene analog and is a selective estrogen receptor modulator.
|
T11818 |
LAS191954
|
1403947-26-1
|
98%
|
|
LAS191954 is a selective, potent and orally active PI3Kδ inhibitor for inflammatory diseases treatment(IC50 : 2.6 nM).
|
TN4213 |
Hirsutenone
|
41137-87-5
|
98%
|
|
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
|
T3229 |
Cytochalasin D
|
22144-77-0
|
98%
|
|
Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertiliz...
|
TN3323 |
Monomethyl lithospermate
|
933054-33-2
|
98%
|
|
Monomethyl lithospermate (Lithospermic acid monomethyl ester) has potential antiviral activity, alleviating ischemic stroke injury in vivo in middle cerebral art...
|
TN3753 |
Dalbergioidin
|
30368-42-4
|
98%
|
|
Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces...
|
TN1367 |
Alismol
|
87827-55-2
|
98%
|
|
Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for ...
|