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Search Results for " nedd8 "

Targets

10

Compounds

1

Natural Products

8

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T8816 NAE-IN-M22 NEDD8 inhibitor M22 Apoptosis , E1/E2/E3 Enzyme
NAE-IN-M22 (NEDD8 inhibitor M22) is a selective, potent and reversible inhibitor of NEDD8 activating enzyme (NAE). NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can i...
T6332 Pevonedistat MLN4924 E1/E2/E3 Enzyme , NEDD8
Pevonedistat (MLN4924) is a potent and selective NEDD8 activating enzyme (NAE) inhibitor (IC50=4.7 nM). Pevonedistat can be used for the treatment of myelodysplastic syndromes (MDS) and also has antitumor activity.
T13090 TAS4464 hydrochloride E1/E2/E3 Enzyme , NEDD8
TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).
T5374 NAcM-OPT E1/E2/E3 Enzyme , NEDD8
NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 (IC50: 79 nM).
T13412 ZM223 ZM-223 E1/E2/E3 Enzyme
ZM223 is an inhibitor of NEDD8 activating enzyme (NAE).
T16102 ML-792 E1/E2/E3 Enzyme
ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. Compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively), ML-792 is an effective and selective inhi...
T16117 Pevonedistat hydrochloride MLN4924 hydrochloride Others
Pevonedistat hydrochloride is an effective and selective inhibitor of NEDD8-activating enzyme (IC50: 4.7 nM).
T13412L ZM223 hydrochloride (2031177-48-5 free base) ZM223 hydrochloride Serine Protease
ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.
T13090L TAS4464 E1/E2/E3 Enzyme
TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM).
T63800 ZM223 hydrochloride
ZM223 hydrochloride is a potent, non-covalent, orally active inhibitor of NEDD8 activase (NAE).
Cat No. Product Name Synonyms Targets
TN1570 Deoxyvasicinone Others
Deoxyvasicinone derivatives can be considered as promising lead molecules for the development of more potent inhibitors of NEDD8-activating enzyme.

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-01132 NEDD8 Protein, Human, Recombinant Human E. coli
Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of cullins is critical for the recrui...
TMPJ-01133 NEDD8 Protein, Human, Recombinant (His & SUMO) Human E. coli
Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of cullins is critical for the recrui...
TMPJ-01278 SENP8 Protein, Human, Recombinant (His) Human E. coli
Sentrin-Specific Protease 8 (SENP8) mediates the reversible covalent modification of proteins by NEDD8. SENP8 catalyzes the full-length NEDD8 to generate its mature form and deconjugation of NEDD8 from targeted proteins ...
TMPY-02214 OTUB1 Protein, Human, Recombinant (His) Human E. coli
Ubiquitin thioesterase OTUB1, also known as Deubiquitinating enzyme OTUB1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Otubain-1, Ubiquitin-specific-processing protease OTUB1, OTUB1 and OTB1, is a cytopla...
TMPY-03869 DCUN1D1 Protein, Human, Recombinant (His) Human E. coli
DCUN1D1, also known as SCCRO, is part of an E3 ubiquitin ligase complex for neddylation. DCUN1D1 functions to recruit charged E2 and is involved in the release of inhibitory effects of CAND1 on cullin-RING ligase E3 comp...
TMPY-01548 UCHL3 Protein, Human, Recombinant (His) Human E. coli
Ubiquitin carboxyl-terminal hydrolase isozyme L3, also known as UCH-L3, Ubiquitin thioesterase L3 and UCHL3, is a ubiquitin-protein hydrolase that belongs to the peptidase C12 family. It is involved both in the processin...
TMPY-02190 UCHL3 Protein, Mouse, Recombinant (His) Mouse E. coli
Ubiquitin carboxyl-terminal hydrolase isozyme L3, also known as UCH-L3, Ubiquitin thioesterase L3 and UCHL3, is a ubiquitin-protein hydrolase that belongs to the peptidase C12 family. It is involved both in the processin...
TMPY-02332 UCHL3 Protein, Rat, Recombinant (His) Rat E. coli
Ubiquitin carboxyl-terminal hydrolase isozyme L3, also known as UCH-L3, Ubiquitin thioesterase L3 and UCHL3, is a ubiquitin-protein hydrolase that belongs to the peptidase C12 family. It is involved both in the processin...
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