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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8816 | NAE-IN-M22 | NEDD8 inhibitor M22 | Apoptosis , E1/E2/E3 Enzyme |
NAE-IN-M22 (NEDD8 inhibitor M22) is a selective, potent and reversible inhibitor of NEDD8 activating enzyme (NAE). NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can i... | |||
T6332 | Pevonedistat | MLN4924 | E1/E2/E3 Enzyme , NEDD8 |
Pevonedistat (MLN4924) is a potent and selective NEDD8 activating enzyme (NAE) inhibitor (IC50=4.7 nM). Pevonedistat can be used for the treatment of myelodysplastic syndromes (MDS) and also has antitumor activity. | |||
T13090 | TAS4464 hydrochloride | E1/E2/E3 Enzyme , NEDD8 | |
TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM). | |||
T5374 | NAcM-OPT | E1/E2/E3 Enzyme , NEDD8 | |
NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 (IC50: 79 nM). | |||
T13412 | ZM223 | ZM-223 | E1/E2/E3 Enzyme |
ZM223 is an inhibitor of NEDD8 activating enzyme (NAE). | |||
T16102 | ML-792 | E1/E2/E3 Enzyme | |
ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. Compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively), ML-792 is an effective and selective inhi... | |||
T16117 | Pevonedistat hydrochloride | MLN4924 hydrochloride | Others |
Pevonedistat hydrochloride is an effective and selective inhibitor of NEDD8-activating enzyme (IC50: 4.7 nM). | |||
T13412L | ZM223 hydrochloride (2031177-48-5 free base) | ZM223 hydrochloride | Serine Protease |
ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity. | |||
T13090L | TAS4464 | E1/E2/E3 Enzyme | |
TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM). | |||
T63800 | ZM223 hydrochloride | ||
ZM223 hydrochloride is a potent, non-covalent, orally active inhibitor of NEDD8 activase (NAE). |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN1570 | Deoxyvasicinone | Others | |
Deoxyvasicinone derivatives can be considered as promising lead molecules for the development of more potent inhibitors of NEDD8-activating enzyme. |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01132 | NEDD8 Protein, Human, Recombinant | Human | E. coli |
Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of cullins is critical for the recrui... | |||
TMPJ-01133 | NEDD8 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of cullins is critical for the recrui... | |||
TMPJ-01278 | SENP8 Protein, Human, Recombinant (His) | Human | E. coli |
Sentrin-Specific Protease 8 (SENP8) mediates the reversible covalent modification of proteins by NEDD8. SENP8 catalyzes the full-length NEDD8 to generate its mature form and deconjugation of NEDD8 from targeted proteins ... | |||
TMPY-02214 | OTUB1 Protein, Human, Recombinant (His) | Human | E. coli |
Ubiquitin thioesterase OTUB1, also known as Deubiquitinating enzyme OTUB1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Otubain-1, Ubiquitin-specific-processing protease OTUB1, OTUB1 and OTB1, is a cytopla... | |||
TMPY-03869 | DCUN1D1 Protein, Human, Recombinant (His) | Human | E. coli |
DCUN1D1, also known as SCCRO, is part of an E3 ubiquitin ligase complex for neddylation. DCUN1D1 functions to recruit charged E2 and is involved in the release of inhibitory effects of CAND1 on cullin-RING ligase E3 comp... | |||
TMPY-01548 | UCHL3 Protein, Human, Recombinant (His) | Human | E. coli |
Ubiquitin carboxyl-terminal hydrolase isozyme L3, also known as UCH-L3, Ubiquitin thioesterase L3 and UCHL3, is a ubiquitin-protein hydrolase that belongs to the peptidase C12 family. It is involved both in the processin... | |||
TMPY-02190 | UCHL3 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Ubiquitin carboxyl-terminal hydrolase isozyme L3, also known as UCH-L3, Ubiquitin thioesterase L3 and UCHL3, is a ubiquitin-protein hydrolase that belongs to the peptidase C12 family. It is involved both in the processin... | |||
TMPY-02332 | UCHL3 Protein, Rat, Recombinant (His) | Rat | E. coli |
Ubiquitin carboxyl-terminal hydrolase isozyme L3, also known as UCH-L3, Ubiquitin thioesterase L3 and UCHL3, is a ubiquitin-protein hydrolase that belongs to the peptidase C12 family. It is involved both in the processin... |