Garvicin KS, GakC

Garvicin KS is a 32-amino-acid peptide that, in collaboration with two other peptides, GakA and GakB, constitutes the bacteriocin GarKS. This compound impairs fibroblast viability and proliferation and exhibits antimicrobial activity against MSSA, demonstrating minimum inhibitory concentration (MIC) values ranked as GakB > GakC > GakA [1].

Garvicin KS (GarKS) is a bacteriocin composed of a 34 amino acid peptide, GakA, and two additional peptides, GakB and GakC. GakA alone has been found to reduce fibroblast viability and proliferation. When combined with GakB, GakA forms an effective duo that exhibits notable peptide stability, antimicrobial potency, and an influence on fibroblast viability and proliferation. Among the Garvicin KS peptides, GakB is the most effective against MSSA, with minimum inhibitory concentration (MIC) values ranked as GakB > GakC > GakA [1].

Garvicin KS (GarKS) is a bacteriocin comprising a 34-amino-acid peptide, GakB, along with two additional peptides, GakA and GakC. GakB specifically impairs fibroblast viability and proliferation. When combined with GakA, GarKS demonstrates enhanced peptide stability, antimicrobial activity, and notable impacts on fibroblast viability and proliferation. Regarding methicillin-sensitive Staphylococcus aureus (MSSA) inhibition, minimum inhibitory concentration (MIC) values rank the peptides in descending order of effectiveness as GakB, followed by GakC, and then GakA [1].