TN4581 |
Moracin D
|
69120-07-6
|
98%
|
|
Moracin C and moracin D, new phytoalexins from diseased mulberry, are antifungal compounds. Moracin may be protective influence in tumor promotion, utilization o...
|
T10702 |
CBP/p300-IN-2
|
2158265-96-2
|
98%
|
|
CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc) extracted from patent WO2017205538A1 (example 25).
|
TN1354 |
Aaptamine
|
85547-22-4
|
98%
|
|
Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner.
|
T11783 |
KSI-3716
|
1151813-61-4
|
98%
|
|
KSI-3716 is an inhibitor of c-Myc.
|
T16839 |
SAJM589
|
2089-82-9
|
98%
|
|
sAJM589 is a Myc inhibitor(IC50: 1.8 μM).
|
TN4582 |
Moracin T
|
1146113-27-0
|
98%
|
|
Moracin treatment can inhibit the double 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment-induced morphological changes reflecting inflammatory response, inc...
|
TN2177 |
Sanggenol L
|
329319-20-2
|
98%
|
|
Sanggenol L shows higher cytotoxicity against human oral tumor cell lines (HSC-2 and HSG) than against normal human gingival fibroblasts (HGF), it induces apopto...
|
TN3708 |
Coronarin D
|
119188-37-3
|
98%
|
|
Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration...
|
T9628 |
10074-A4
|
312631-87-1
|
98%
|
|
10074-A4 is a c-Myc binding compound that associates with c-Myc370–409 and behaves like a “ligand cloud” around a “protein cloud”, with distinct features from th...
|
T15665 |
KJ Pyr 9
|
581073-80-5
|
98%
|
|
KJ Pyr 9 is an MYC inhibitor (Kd: 6.5 nM in vitro assay).
|
T3686 |
10074-G5
|
413611-93-5
|
98%
|
|
10074-G5 is an inhibitor of c-Myc-Max dimerization.
|
T12134 |
MYCMI-6
|
681282-09-7
|
98%
|
|
MYCMI-6 is a potent and selective inhibitor of endogenous MYC:MAX protein interactions,reduces proliferation and induces massive apoptosis in tumor tissue from a...
|
T9061 |
EN4
|
1197824-15-9
|
98%
|
|
EN4 MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC. It is selective for c-MYC over N-MYC and L-MYC, and inhibits MYC transcriptional ...
|
T4367 |
Mycro 3
|
944547-46-0
|
98%
|
|
Mycro 3 is potent and selective for c-Myc in whole cell assays.
|
TN1892 |
Lusianthridin
|
87530-30-1
|
98%
|
|
Lusianthridin is a natural product from Dendrobium venustum. Lusianthridin exhibits anti-migratory property at nontoxic concentrations. Lusianthridin enhances c-...
|
T12132 |
MYCi361
|
2289690-31-7
|
98%
|
|
MYCi361 is an inhibitor of MYC (binding to MYC with Kd of 3.2 μM).
|
T12133 |
MYCi975
|
2289691-01-4
|
98%
|
|
MYCi975 is an orally active inhibitor of MYC.
|
T10352 |
APTO-253
|
916151-99-0
|
98%
|
|
APTO-253 inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates a...
|
T4252 |
ML327
|
1883510-31-3
|
98%
|
|
ML327 is a MYC blocker. ML327 can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).
|
T9093 |
NY2267
|
886053-73-2
|
98%
|
|
NY2267 is a disruptor of Myc-Max interaction, with an IC50 of 36.5 μM.
|