TN1086 |
Dehydrotrametenolic acid
|
6879-05-6
|
|
|
Dehydrotrametenolic acid (Dehydroeburicoic acid) induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in ...
|
T6724 |
Voreloxin
|
175414-77-4
|
98%
|
|
Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
|
TN1694 |
Gliotoxin
|
67-99-2
|
98%
|
|
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signalin...
|
T77713 |
BTM-3566
|
2228857-70-1
|
98%
|
|
BTM-3566 activates the ISR through the mitochondrial protease OMA1.BTM-3566 induces apoptosis in cancer cells. BTM-3566 overactivates the mitochondrial ISR to st...
|
T78054 |
JNJ-1013
|
2597343-08-1
|
98%
|
|
JNJ-1013 is a potent and selective IRAK1 degrader, demonstrating IC50 values of 72 nM for IRAK1, 443 nM for IRAK4, and 1071 nM for VHL FP. It induces apoptosis a...
|
T78404 |
Pyridinium bisretinoid A2E TFA
|
1821308-73-9
|
98%
|
|
Pyridinium bisretinoid A2E (A2E) TFA, a fluorophore derived from retinal pigment epithelium (RPE) lipofuscin, initiates blue-light-induced apoptosis, mediates au...
|
T78569 |
CPT2
|
1670277-66-3
|
98%
|
|
Carnitine palmitoyltransferase 2 (CPT2), an enzyme involved in fatty acid oxidation, serves as a prognostic biomarker for colorectal cancer (CRC). Overexpression...
|
T78586 |
Ac-IETD-CHO
|
191338-86-0
|
98%
|
|
Ac-IETD-CHO is a potent, reversible inhibitor of granzyme B and caspase 8, which also impedes Fas-mediated apoptosis, hemorrhagic conditions, and liver failure. ...
|
T78608 |
Anticancer agent 164
|
2235393-30-1
|
98%
|
|
CML-IN-1, also known as compound 7 and compound 4, is a potent anticancer agent that demonstrates a strong induced-apoptosis effect in the human chronic myeloid ...
|
T78612 |
APPA
|
100750-39-8
|
98%
|
|
APPA, an aldose reductase inhibitor, demonstrates efficacy in preventing apoptosis and symptoms of Streptozotocin-induced diabetes in rats through inhibition of ...
|
T78686 |
Apoptosis inducer 11
|
|
98%
|
|
Apoptosis Inducer 11 (compound 3u) promotes apoptosis via the mitochondrial pathway and elicits a G2/M block alongside a marked reduction in the S phase within n...
|
T78742 |
Anticancer agent 132
|
|
98%
|
|
Compound Rh1 (Anticancer agent 132) acts as an inducer of apoptosis and autophagy, exhibiting both antitumor and antimetastatic activities. It also arrests the c...
|
T78743 |
Anticancer agent 133
|
|
98%
|
|
Compound Rh2 (Anticancer agent 133) is a cytotoxic and antimetastatic agent that induces cell cycle arrest, apoptosis, and autophagy. Additionally, it suppresses...
|
T78764 |
Anticancer agent 136
|
|
98%
|
|
Anticancer agent 136 (compound 22), a C17-triazole analogue of Geldanamycin (GDM), exhibits an IC50 value of 3.38 μM against human dermal fibroblasts (HDF) and b...
|
T78846 |
EP12
|
2882916-73-4
|
98%
|
|
EP12, a c-Myc inhibitor and G4 stabilizer, induces apoptosis and DNA damage in multiple myeloma cells while obstructing P65/P50 nuclear translocation by disrupti...
|
T78904 |
Anticancer agent 110
|
887349-03-3
|
98%
|
|
Anticancer Agent 110 exhibits potent in vitro anti-leukemia activity, demonstrating high cytotoxicity against K-562 lineage chronic myelogenous leukemia cells at...
|
T78909 |
Antitumor agent-97
|
2654024-16-3
|
98%
|
|
Antitumor agent-97 (compound 42), an anticancer agent, effectively inhibits proliferation and autophagy in MGC 803 cells, induces apoptosis, and enhances ROS acc...
|
T78911 |
Antitumor agent-112
|
|
98%
|
|
Antitumor agent-112 (compound 3a) is a potent antitumor agent that induces apoptosis and exhibits cytotoxic activity on A549 cells, with an IC50 value of 91.35 μ...
|
T78912 |
Antitumor agent-113
|
|
98%
|
|
Antitumor Agent-113 exhibits cytotoxicity in A549 cells, with an IC50 of 46.60 μM, and induces apoptosis, making it applicable for research in non-small cell lun...
|
T78940 |
EGFR-IN-78
|
|
98%
|
|
EGFR-IN-78 (compound A5), a 2-aminopyrimidine derivative, serves as a reversible EGFR C797S-TK inhibitor and an apoptosis inducer. It exhibits anti-proliferative...
|