ca ix-in-3

CAIX-IN-3 (Compound 27) is a selective and potent inhibitor of carbonic anhydrase IX (CAIX), with an IC50 of 0.48 nM.

CAIX VEGFR-2-IN-3 (Compound 6i) is an inhibitor of Carbonic Anhydrase IX and VEGFR-2, with IC50 values of 41 and 48 nM, respectively. It exhibits anticancer activity by inhibiting the growth of MCF-7 breast cancer cells (IC50 of 22.33 μM) and mouse fibroblast cell line 3T3, where cell viability is reduced to below 40% at a concentration of 100 μM. This compound is applicable for research in the field of cancer treatment.

hCAII-IN-3 (compound 7e) is a selective and potent inhibitor of carbonic anhydrase (CA II IX), with Ki values of 124.2 nM and 30.5 nM, respectively. hCAII-IN-1 shows investigational potential for cancer disease.