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Cat No. | Product Name | Synonyms | Targets |
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T67727 | MCT1-IN-3 | Monocarboxylate transporter | |
MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor. The solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) represents a promising target for the treatment of cancer. MCT1-IN-3 (compound 24) sho... | |||
T26221 | MCT1-IN-2 | SR13800,SR-13800,SR 13800 | |
SR13800 is a monocarboxylate transporter 1 (MCT1) inhibitor with cell-permeable. | |||
T9235 | GW604714X | 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- | Mitochondrial Metabolism |
GW604714X (2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-) were found to be potent inhibitors of mitochondrial respiration supported by pyruvate | |||
T5208 | BAY-8002 | BAY8002,BAY 8002 | Monocarboxylate transporter |
BAY-8002 is a potent dual MCT1/2 inhibitor (IC50 values are 3, 8, and 12 nM at rat (C6), human (DLD-1) and mouse (4T1) MCT1 respectively). | |||
T3210 | AZD3965 | AZD 3965,AZD-3965 | Monocarboxylate transporter |
AZD3965 (AZD-3965) is a selective inhibitor of monocarboxylate transporter 1 (MCT1). | |||
T14316 | AR-C155858 | Monocarboxylate transporter | |
AR-C155858 is an inhibitor of monocarboxylate transporter MCT1 and MCT2 (Kis: 2.3 nM and 10 nM). | |||
T60165 | VB124 | Monocarboxylate transporter | |
VB124 is an orally active, potent, and selective MCT4 inhibitor, demonstrating specificity in hindering lactate efflux, with IC50 values of 8.6 nM and 19 nM for lactate import and export, respectively, in MDA-MB-231 cell... | |||
T7460 | α-Cyano-4-hydroxycinnamic acid | α-Cyano-4-hydroxycinnamic acid(α-CHCA) | Monocarboxylate transporter |
α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamic acid(α-CHCA)) (α-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate transport in rat heart mitochondria (IC50 : 1.5 μM). | |||
T5845 | 7ACC1 | DEAC,Coumarin D 1421,7-(Diethylamino)coumarin-3-carboxylic acid,D 1421 | Monocarboxylate transporter |
7ACC1 (D 142) selectively affects a single part of the MCT symporter translocation cycle, leading to strict inhibition of lactate influx. This singular activity is associated with antitumor effects less prone to resistan... | |||
T37822 | AR-C 141990 hydrochloride | ||
Monocarboxylate transporter (MCT1) inhibitor (pKi = 7.6. Exhibits approximately 10-fold selectivity for MCT1 over MCT2 and no significant activity against MCT3 or 4. Inhibits graft versus host response and prolongs card... | |||
T69853 | AR-C117977 | ||
AR-C117977 is a potent MCT1 inhibitor, which can reduce vimmune responses both in vitro and in vivo, maintains long-term graft survival, and induces operational tolerance. |
Cat No. | Product Name | Synonyms | Targets |
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TN2252 | Syrosingopine | Dopamine Receptor | |
Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor. |
Cat No. | Product Name | Species | Expression System |
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TMPY-02574 | Chymase 1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
The STR polymorphism in the CMA1 gene is associated with asthma and that this association is even stronger with atopic asthma. CMA1 and IL-4 in atopic asthma and for IL-4 in atopy in general. The local angiotensin II sys... |