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Cat No. | Product Name | Synonyms | Targets |
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T79023 | CaSR antagonist-1 | CaSR | |
CaSR Antagonist-1 is a potent inhibitor of the calcium-sensing receptor (CaSR) with an inhibitory concentration (IC50) of 50 nM, suitable for the investigation of diseases related to dysregulated bone or mineral homeosta... | |||
T12846 | SB-423562 | CaSR | |
SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis. | |||
T15261 | Evocalcet | KHK7580 | CaSR |
Evocalcet (KHK7580) has an activating effect on the calcium-sensing receptor (CaSR). | |||
T8457 | NPS2390 | GluR | |
NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively) | |||
T8403 | Cinacalcet | AMG 073 | CaSR |
Cinacalcet (AMG 073) is an orally active, allosteric Ca receptor (CaR) agonist, treatment of cardiovascular disease . | |||
T22795 | Gadolinium chloride | CaSR | |
Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist | |||
T1641 | Strontium ranelate | Distrontium renelate,S12911 | Calcium Channel , CaSR |
Strontium ranelate (S12911), a strontium (II) salt of the ranelic acid, is a medication for osteoporosis. Studies indicate it can also slow the course of osteoarthritis of the knee. The drug is unusual in that it both in... | |||
T2406 | Cinacalcet hydrochloride | AMG-073 HCl,Cinacalcet HCl,AMG-073 hydrochloride,Cinacalcet | CaSR |
Cinacalcet hydrochloride (AMG-073 hydrochloride) is a naphthalene derivative and CALCIMIMETIC AGENT that increases the sensitivity of PARATHYROID GLAND calcium-sensing receptors to serum calcium. This action reduces para... | |||
TP1236 | Etelcalcetide hydrochloride | AMG 416 hydrochloride,KAI-4169 hydrochloride | CaSR |
Etelcalcetide hydrochloride (AMG 416 hydrochloride) is a synthetic peptide that acts as an allosteric modulator of the calcium-sensing receptor (CaSR), effectively lowering parathyroid hormone (PTH) levels in patients wi... | |||
T1730 | NPS-2143 | SB262470,NPS 2143,SB 262470A | Calcium Channel , CaSR |
NPS-2143 (SB 262470A) is a novel potent and selective antagonist of Ca(2+) receptor. | |||
T4967 | NPS-2143 hydrochloride | NPS-2143 HCL | CaSR |
NPS-2143 hydrochloride (NPS-2143 HCL) is a selective potent calcium ion-sensing receptor antagonist. | |||
T40363 | Poly-D-lysine hydrobromide (MW 30000-70000) | Poly-D-lysine HBr (MW 30000-70000) | CaSR |
Poly-D-lysine hydrobromide (MW 30000-70000)(Poly-D-lysine HBr) is an orally available peptide CaSR agonist that removes proteinase K-resistant PrP from prion-infected SN56 neuroblastoma cells. | |||
T23401 | Strontium chloride | Others , CaSR | |
Strontium chloride is an agonist of Calcium sensing receptor (CaSR) and directly affects C-type nerve fibers. | |||
T7716 | TNCA | Lycoperodine-1 | Others |
TNCA (Lycoperodine-1) is a high-affinity CaSR ligand (CaSRL) with co-agonist activity. | |||
T13918 | Tecalcet Hydrochloride | R-568 hydrochloride,R-568 (hydrochloride) | CaSR |
Tecalcet Hydrochloride (R-568 hydrochloride) is an allosteric and positive modulator of the calcium-sensing receptor(CaSR). Tecalcet Hydrochloride increases the sensitivity to the activation of extracellular Ca2+. | |||
T34385 | Ronacaleret HCl | SB 751689,SB 751689A,SB-751689A,SB-751689,SB751689A,SB751689 | CaSR |
Ronacaleret HCl (SB-751689) is a small molecule CaSR antagonist for the treatment of endocrine and metabolic diseases, skin and musculoskeletal disorders. | |||
T29541 | AC265347 | AC-265347 | CaSR |
AC265347 is a potent calcium-sensitive receptor (CaSR) agonist and ago-PAM orthosteric modulator with antitumour activity that inhibits neuroblastoma tumour growth by inducing differentiation.AC265347 can be used to stud... | |||
T10666 | Calhex 231 hydrochloride | CaSR | |
Calhex 231 hydrochloride is a CaSR inhibitor with the potential for diabetic cardiomyopathy treatment. It blocks Ca2+-induced accumulation of [3H]inositol phosphate (IC50: 0.39 μM in HEK293 cells). | |||
T11493 | GSK3004774 | Others | |
GSK3004774 is a nonabsorbable agonist of CaSR (pEC50: 7.3, 6.6, and 6.5 for human, mouse, and rat CaSR). GSK3004774 shows an EC50 of 50 nM for human CaSR. | |||
TP1235 | Etelcalcetide | AMG 416,KAI-4169 | |
Etelcalcetide (AMG 416) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is a calcimimetic drug for the treatment of secondary hyperparathyroidism in patients undergoing hemodi... | |||
T31624 | Encaleret | JIT305,JIT 305 | |
Encaleret( JIT-305) is an antagonist of oral calcium-sensing receptor (CaSR), it is used for the treatment of osteoporosis. | |||
T21758 | Calindol (hydrochloride) | ||
Calindol (hydrochloride) is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM. | |||
T72908 | Gamma-Glu-Abu | ||
Gamma-Glu-Abu is a potent calcium sensing receptor (CaSR) agonist . | |||
T12845 | SB-423557 | Calcium Channel | |
SB-423557 is an orally active antagonist of calcium-sensing receptor (CaR) with IC50 of 520 nM |
Cat No. | Product Name | Synonyms | Targets |
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T3802 | Ligustroflavone | Nuezhenoside | Others , CaSR |
Ligustroflavone (Nuezhenoside) has anti-inflammatory activity. |
Cat No. | Product Name | Species | Expression System |
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TMPH-01315 | CASR Protein, Human, Recombinant (GST) | Human | E. coli |