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Search Results for " ask "

Targets

10

Compounds

1

Natural Products

6

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T13099 TC ASK 10 ASK , MAPK
TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1)(IC50 of 14 nM).
T22254 Alflutinib AST2818,ASK120067 EGFR , P450
Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.
T9697 ASK1-IN-1 ASK
ASK1-IN-1 is an inhibitor of apoptosis signal-regulating kinase 1 which is a key mediator in the apoptotic and inflammatory cellular stress response with an IC50 of 21 nM in biochemica assays.
T35897 ASK120067
ASK120067 is a potent and orally active inhibitor of EGFRT790M (IC50:0.3 nM) with selectivity over EGFRWT (IC50:6.0 nM). ASK120067 is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC)[1]...
T9377 ASK1-IN-2 Apoptosis , ASK , MAPK
ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 can potentially be used as a therapeutic strategy for ulcerative colitis[1].
T67857 ASK1-IN-4 ASK
ASK1-IN-4 is an ASK1 inhibitor, IC50 = 0.2 μM.
T72064 TASK-1-IN-1 Potassium Channel
TASK-1-IN-1 is a potent and selective inhibitor of TASK-1 (Potassium Channel) (IC50: 148 nM).TASK-1-IN-1 has a reduced inhibitory effect on the TASK-3 channel with an IC50 of 1750 nM.TASK-1-IN-1 has anticancer effects.
T73221 CASK-IN-1
CASK-IN-1 is a highly potent and selective CASK inhibitor with a K d value of 0.022 μM.
T61584 ASK1-IN-3
ASK1-IN-3 is a highly potent and selective inhibitor of ASK1 kinase, demonstrating an IC 50 of 33.8 nM. This compound also exhibits inhibitory effects on various cell cycle regulating kinases. ASK1-IN-3 showcases remarka...
T22418 S-99 Others
S-99 is a high purity chemical that targets ASK and is important for Immunology, Inflammation, Cancer research.
Cat No. Product Name Synonyms Targets
TN4635 Neoechinulin A NADPH-oxidase , Beta Amyloid , ASK , IκB/IKK , p38 MAPK , TNF , NOS , NF-κB , COX , Prostaglandin Receptor
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the phosphorylation of mitogen-activated protein kinase (MAPK) ...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-04563 CASK Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Peripheral plasma membrane protein CASK, also known as calcium/calmodulin-dependent serine protein kinase, CASK and LIN2, is a nucleus, cytoplasm and cell membrane protein which belongs to theMAGUK family. CASK / LIN2...
TMPY-05906 Influenza A H1N1 (A/swine/Saskatchewan/SD0056/2014) Hemagglutinin/HA Protein (His) H1N1 HEK293
The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two...
TMPH-03417 Rotavirus A (strain Nebraska calf diarrhea virus) VP6 Protein (His) RV-A E. coli
Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middl...
TMPH-03422 Rotavirus A (strain Nebraska calf diarrhea virus) VP7 Protein (His & Myc) RV-A E. coli
Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts ...
TMPY-04754 CASK Protein, Human, Recombinant Human Baculovirus-Insect Cells
Peripheral plasma membrane protein CASK, also known as calcium/calmodulin-dependent serine protein kinase, CASK and LIN2, is a nucleus, cytoplasm and cell membrane protein which belongs to theMAGUK family. CASK / LIN2...
TMPH-03424 Rotavirus A (strain Nebraska calf diarrhea virus) VP4 Protein (His & Myc) RV-A E. coli
Spike-forming protein that mediates virion attachment to the host epithelial cell receptors and plays a major role in cell penetration, determination of host range restriction and virulence. Rotavirus attachment and entr...
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