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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T15481 | HI-TOPK-032 | TOPK | |
HI-TOPK-032 is an effective and specific inhibitor of TOPK. | |||
T61440 | TOPK-p38/JNK-IN-1 | ||
TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NO production. It demonstrates anti-inflammatory properties by inh... | |||
T4135 | OTS964 hydrochloride | OTS964 | Apoptosis , TOPK , CDK |
OTS964 hydrochloride (OTS964) is a potent and selective TOPK inhibitor with potential anticancer activity. | |||
T1756L | Ilaprazole | IY81149,IY 81149,IY-81149 | Proton pump , TOPK |
Ilaprazole (IY-81149) is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Studies also showed that Ilaprazole significantly prevented the developm... | |||
T1756 | Ilaprazole sodium | IY-81149 sodium | Proton pump , TOPK |
Ilaprazole sodium (IY-81149 sodium) , a substituted benzimidazole prodrug, is a selective and irreversible proton pump inhibitor. A weak base, Ilaprazole accumulates in the acidic environment of the secretory canaliculus... | |||
T0199 | Cephradine | Anspor,Cephradin,Velosef,SQ-11436,Sefril | TOPK , Antibacterial , Antibiotic |
Cephradine (Anspor) is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. | |||
T4134 | OTS514 hydrochloride | OTS-514 hydrochloride,OTS514 hydrochloride(1338540-63-8(free base)) | Apoptosis , TOPK |
OTS514 hydrochloride is a highly effective TOPK(T-LAK cell-originated protein kinase) inhibitor (IC50: 2.6 nM). | |||
T4134L | OTS514 | OTS514 HCl,OTS514 Hydrochloride,OTS-514,OTS 514 | Apoptosis , TOPK |
OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell lines (IC50: 0.4 ~ 42.6 nM). Treatmen... | |||
T69727 | ADA-07 | ||
ADA-07 is a TOPK inhibitor which interacts with TOPK at the ATP-binding pocket and inhibits its kinase activity, thereby suppressing SUV-induced phosphorylation of ERK1/2, p38, and JNKs, and subsequently inhibiting AP-1 ... | |||
T61800 | OTS964 | ||
OTS964 is a potent, orally active compound that operates as a highly selective inhibitor of TOPK with an IC 50 of 28 nM [1]. Additionally, it demonstrates significant inhibitory action against cyclin-dependent kinase CDK... | |||
T78218 | Ilaprazole sodium hydrate | IY-81149 sodium hydrate | Proton pump |
Ilaprazole (IY-81149) sodium hydrate is an orally active proton pump inhibitor that irreversibly inhibits H+/K+-ATPase in rabbit parietal cells with a dose-dependent IC50 of 6 μM. It is employed in gastric ulcer research... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04547 | PBK/TOPK Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the chara... |