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Search Results for " topk "

Targets

11

Compounds

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T15481 HI-TOPK-032 TOPK
HI-TOPK-032 is an effective and specific inhibitor of TOPK.
T61440 TOPK-p38/JNK-IN-1
TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NO production. It demonstrates anti-inflammatory properties by inh...
T4135 OTS964 hydrochloride OTS964 Apoptosis , TOPK , CDK
OTS964 hydrochloride (OTS964) is a potent and selective TOPK inhibitor with potential anticancer activity.
T1756L Ilaprazole IY81149,IY 81149,IY-81149 Proton pump , TOPK
Ilaprazole (IY-81149) is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Studies also showed that Ilaprazole significantly prevented the developm...
T1756 Ilaprazole sodium IY-81149 sodium Proton pump , TOPK
Ilaprazole sodium (IY-81149 sodium) , a substituted benzimidazole prodrug, is a selective and irreversible proton pump inhibitor. A weak base, Ilaprazole accumulates in the acidic environment of the secretory canaliculus...
T0199 Cephradine Anspor,Cephradin,Velosef,SQ-11436,Sefril TOPK , Antibacterial , Antibiotic
Cephradine (Anspor) is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.
T4134 OTS514 hydrochloride OTS-514 hydrochloride,OTS514 hydrochloride(1338540-63-8(free base)) Apoptosis , TOPK
OTS514 hydrochloride is a highly effective TOPK(T-LAK cell-originated protein kinase) inhibitor (IC50: 2.6 nM).
T4134L OTS514 OTS514 HCl,OTS514 Hydrochloride,OTS-514,OTS 514 Apoptosis , TOPK
OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell lines (IC50: 0.4 ~ 42.6 nM). Treatmen...
T69727 ADA-07
ADA-07 is a TOPK inhibitor which interacts with TOPK at the ATP-binding pocket and inhibits its kinase activity, thereby suppressing SUV-induced phosphorylation of ERK1/2, p38, and JNKs, and subsequently inhibiting AP-1 ...
T61800 OTS964
OTS964 is a potent, orally active compound that operates as a highly selective inhibitor of TOPK with an IC 50 of 28 nM [1]. Additionally, it demonstrates significant inhibitory action against cyclin-dependent kinase CDK...
T78218 Ilaprazole sodium hydrate IY-81149 sodium hydrate Proton pump
Ilaprazole (IY-81149) sodium hydrate is an orally active proton pump inhibitor that irreversibly inhibits H+/K+-ATPase in rabbit parietal cells with a dose-dependent IC50 of 6 μM. It is employed in gastric ulcer research...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-04547 PBK/TOPK Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the chara...
TargetMol