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Search Result

Search Results for " pkm "

Targets

PKM PKM

12

Compounds

6

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T4170 PKM2-IN-1 PKM2 inhibitor,compound 3k PKM
PKM2-IN-1 (compound 3k) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
T39984 PKM2-IN-3 PKM2-IN-3
PKM2-IN-3 is a potent PKM2 kinase inhibitor, displaying an IC 50 value of 4.1 μM. The compound effectively suppresses PKM2-mediated glycolysis and NLRP3 activation, thereby exerting an anti-neuroinflammatory effect.
T67900 PKM2 inhibitor G PKM
PKM2 inhibitor G is a inhibitor of pyruvate kinase.
T62758 PKM2 activator 2 PKM
PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activator with an AC 50 value of 66 nM.PKM2 activator 2 has anti-tumor proliferative properties and attenuates the Warburg effect by normalizing cellular glycolytic metabol...
T81446 PKM2 activator 6
Compound Z10 (PKM2 activator 6) serves as both a PKM2 activator and a PDK1 inhibitor, exhibiting dissociation constants (K D ) of 121 μM and 19.6 μM, respectively. It promotes apoptosis in colorectal cells while suppress...
T61504 PKM2 activator 3
PKM2 activator 3 is a highly potent compound that activates PKM2, with an AC 50 value of 90 nM. It exhibits excellent Caco-2 permeability, a low efflux ratio, and remarkable microsomal stability. PKM2 activator 3 is part...
T79636 PKM2-IN-4
Compound 5C, referred to as Pkm2-in-4, is a selective PKM2 inhibitor (IC50 = 0.35 µM) that modulates pyruvate-dependent respiration and promotes mitochondrial H2O2 production rate and electron transport system coupling [...
T71867 PKM2 inhibitor 2825-0090
PKM2 inhibitor 2825-0090 is a Novel pyruvate kinase M2 (PKM2) inhibitor, reducing tumor growth of NSCLC xenografts in vivo.
T72692 PKM2 activator 4
PKM2 Activator 4, a chemical compound, functions as an activator of PKM2 with an activation concentration (AC 50) ranging from 1 to 10 μM. It is primarily utilized in cancer research.
T74814 PKM2/PDK1-IN-1
PKM2/PDK1-IN-1, a shikonin thioether derivative, serves as a dual inhibitor for PKM2/PDK1. This compound effectively inhibits the proliferation and induces apoptosis in NSCLC cells. It promotes intercellular ROS producti...
T72693 PKM2 activator 5 PKM
PKM2 activator 5 is a novel and potent PKM2 activator (AC50: 0.316 µM) with potential anticancer activity for the study of cancer metabolism-related diseases.
T79520 HMG-CoA Reductase-IN-1
HMG-CoA Reductase-IN-1 is an inhibitor of HMG-CoA reductase, demonstrating strong inhibitory activity on HMGR and affinity for OATP1B1, with pIC50 and pKm values of 8.54 and 1.98, respectively. It is utilized in hypercho...

Recombinant Proteins

Species：
Mouse (3)
Rat (2)
Human (1)
Expression System：
E. coli (3)
Baculovirus (2)
Baculovirus-Insect Cells (1)
Tag：
N-terminal 10xHis-tagged and C-terminal Myc-tagged (4)
His (2)
Cat No. Product Name Species Expression System
TMPY-04465 PKM2 Protein, Human, Recombinant (His) Human E. coli
Pyruvate kinase isozymes M2 also known as pyruvate kinase muscle isozyme 2 (PKM2), pyruvate kinase type K, cytosolic thyroid hormone-binding protein (CTHBP), thyroid hormone-binding protein 1 (THBP1), or opa-interacting ...
TMPH-03362 PKM2 Protein, Rat, Recombinant (His & Myc) Rat Baculovirus
PKM2 Protein, Rat, Recombinant (His & Myc) is expressed in Baculovirus.
TMPH-03363 PKM2 Protein, Rat, Recombinant (E. coli, His & Myc) Rat E. coli
PKM2 Protein, Rat, Recombinant (E. coli, His & Myc) is expressed in E. coli.
TMPH-02872 PKM2 Protein, Mouse, Recombinant (E. coli, His & Myc) Mouse E. coli
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines w...
TMPH-02871 PKM2 Protein, Mouse, Recombinant (His & Myc) Mouse Baculovirus
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines w...
TMPY-04766 PKM2 Protein, Mouse, Recombinant (His) Mouse Baculovirus-Insect Cells
Pyruvate kinase isozymes M2 also known as pyruvate kinase muscle isozyme 2 (PKM2), pyruvate kinase type K, cytosolic thyroid hormone-binding protein (CTHBP), thyroid hormone-binding protein 1 (THBP1), or opa-interacting ...
Cat No. Product Name
L2130 Anti-Cancer Metabolism Compound Library

1280 compounds
A unique collection of 1280 cancer cellular metabolism related compounds for cancer research and high throughput screening (HTS) and high content screening (HCS);

Libraries

Anti-Cancer Metabolism Compound Library
L2130
Compounds: 1280
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