flap — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T81181	SEH/FLAP-IN-1		FLAP
	sEH/FLAP-IN-1 (Compound 46A) serves as a dual inhibitor targeting both sEH and FLAP. It effectively suppresses 5-LOX product formation with an EC50 of 11 nM in SACM-stimulated PBMCs and also inhibits sEH activity (EC50: ...		FLAP
T8844	Diflapolin		Others , FLAP , Epoxide Hydrolase
	Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity.		Others , FLAP , Epoxide Hydrolase
T9023	Atuliflapon	AZD5718	FLAP
	Atuliflapon (AZD5718) is a novel 5-Lipoxygenase Activating Protein(FLAP) inhibitor for Treatment of Coronary Artery Disease.		FLAP
T16087	Quiflapon	MK-591	Apoptosis , FLAP
	Quiflapon (MK-591) causes cell apoptosis. Quiflapon is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor (IC50: 1.6 nM in a FLAP binding assay) and is also an effective and orally active Leukotr...		Apoptosis , FLAP
T8545	FEN1-IN-4	FEN1 Inhibitor C2	Others
	FEN1-IN-4 (FEN1 Inhibitor C2) is an inhibitor of human flap endonuclease-1 (hFEN1)		Others
T6893	MK-886	MK886,L 663536	Apoptosis , Leukotriene Receptor , COX , PPAR , FLAP
	MK-886 (L 663536) is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.		Apoptosis , Leukotriene Receptor , COX , PPAR , FLAP
T11487	Fiboflapon	GSK2190915,AM-803	FLAP
	Fiboflapon (GSK2190915) is an orally available and effective 5-lipoxygenase-activating protein (FLAP) inhibitor that binds FLAP with a titer of 2.9 nM and inhibition of LTB4 in human blood with an IC50 of 76 nM.		FLAP
TQ0098	Quiflapon sodium	MK591	FLAP
	Quiflapon sodium (MK591) is a selective inhibitor of 5-Lipoxygenase-activating protein (FLAP).		FLAP
T11487L	Fiboflapon sodium	GSK2190915 sodium salt,AM-803 sodium	LTR
	Fiboflapon sodium (GSK2190915) is an orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC50 of 76 nM for inhibition of LTB4 in human blood.		LTR
T13295	Veliflapon	DG-031,BAY X 1005	LTR
	Veliflapon is an orally active and selective inhibitor of 5-lipoxygenase activating protein (FLAP). Veliflapon inhibits the synthesis of the leukotrienes B4 and C4.		LTR
T77172	Eflapegrastim
	Eflapegrastim, a humanized IgG4 monoclonal antibody and granulocyte colony-stimulating factor (G-CSF), targets the G-CSF receptor (c-Fms). It promotes the proliferation and differentiation of neutrophil progenitor cells,...
T10314	AM103	AM 103	FLAP
	AM103 is an effective and selective inhibitor of FLAP (IC50 = 4.2 nM).		FLAP
T9147	FEN1-IN-3
	FEN1-IN-3 is a human flap endonuclease-1 ( hFEN1 ) inhibitor that stabilizes hFEN1 with an EC 50 of 6.8 μM .
T15274	FEN1-IN-1	LNT-1	Others
	FEN1-IN-1 (LNT-1) is an inhibitor of flap endonuclease 1 (FEN1). FEN1-IN-1 binds to the active site of FEN1. It partly achieves inhibition by the co-ordination of Mg2+ ions.		Others
T12793	(S)-BI 665915		Others
	(S)-BI 665915 is an orally active inhibitor of oxadiazole-containing 5-lipoxygenase-activating protein (FLAP)(IC50 of 1.7 nM for FLAP binding)..		Others
T69128	NSC-13755
	NSC-13755 is a human flap endonuclease 1 (FEN1) inhibitor.
T14205	AM679		Others
	AM679 is a potent and selective FLAP inhibitor with IC50s of 2.2 nM/0.6 nM/154 nM for FLAP binding/hLA/hWB respectively. IC50 value: 2.2 nM/0.6 nM/154 nM(FLAP binding/hLA/hWB) [1] AM679 showed an improved CYP inhibition ...		Others
T68449	JFD00950
	JFD00950 is a human flap endonuclease 1 (FEN1) inhibitor with in vitro inhibition of flap cleavage activity as well as cytotoxic activity against a colon cancer cell line, DLD-1.
T69418	AM-679
	AM-679 is a 5-lipoxygenase-activating protein (FLAP) inhibitor.
T78192	FEN1-IN-5		FLAP
	FEN1-IN-5 (compound 12A) is a potent Flap endonuclease-1 (FEN1) inhibitor with an IC50 value of 12 nM, playing a role in DNA repair mechanisms [1].		FLAP
T70316	AZD6642
	AZD6642 is a potential and selective 5-Lipoxygenase activating Protein (FLAP) inhibitor. AZD6642 shows high specific potency and low lipophilicity resulting in a selective and metabolically stable profile. Based on initi...
T79389	LTB4-IN-2		FLAP
	LTB4-IN-2 (Compound 6x) is a selective inhibitor of Leukotriene B4 (LTB4), acting by specifically targeting the 5-Lipoxygenase-activating protein (FLAP) with an inhibitory concentration (IC 50) of 1.15 μM, thus serving a...		FLAP
T79134	FEN1-IN-6		FLAP
	FEN1-IN-6 (compound 9) is a potent Flap endonuclease-1 (FEN1, IC50 = 10 nM) inhibitor, crucial for DNA damage repair in mammalian cells, and additionally targets the related endonuclease xeroderma pigmentosum G (XPG) wit...		FLAP
T79135	FEN1-IN-7		FLAP
	FEN1-IN-7 (compound 16), a selective Flap endonuclease-1 (FEN1) inhibitor with an IC50 of 18 nM, plays a role in DNA damage repair in mammalian cells. Additionally, it targets the related endonuclease, xeroderma pigmento...		FLAP
T40931	FEN1-IN-2	FEN1-IN-2	Others
	FEN1-IN-2 is a selective and potent inhibitor of flap endonuclease 1 (FEN1), inhibits FEN1 and XPG, has potential anticancer activity, and can be used to study DNA damage repair.		Others
T69970	AZD5718
	AZD5718 is a potent and selective FLAP inhibitor (IC50 = 2.0 nM) for Treatment of Coronary Artery Disease. AZD5718 demonstrated a dose dependent and greater than 90% suppression of leukotriene production over 24 h. Precl...
T37649	5(S),12(S)-DiHETE
	5(S),12(S)-DiHETE is a natural bioactive lipid derived from arachidonic acid . It is synthesized by glycogen-induced rabbit peritoneal polymorphonuclear leukocytes (PMNLs) incubated with AA. 5(S),12(S)-DiHETE can be prod...

Compounds

sEH/FLAP-IN-1

T81181

Target: Others, FLAP, Epoxide Hydrolase

Target: Apoptosis, FLAP

FEN1-IN-4

T8545

Synonym: FEN1 Inhibitor C2

Target: Others

MK-886

T6893

Synonym: MK886,L 663536

Target: Apoptosis, Leukotriene Receptor, COX, PPAR, FLAP

Fiboflapon

T11487

Synonym: GSK2190915,AM-803

Synonym: GSK2190915 sodium salt,AM-803 sodium

Target: LTR

Veliflapon

T13295

Synonym: DG-031,BAY X 1005

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01481	FLAP Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP), also known as FLAP, belongs to the MAPEG family. ALOX5AP/FLAP is an essential partner of 5-LO for this process. The FLAP (ALOX5AP) gene has been linked to risk fo...
TMPH-01344	Flap endonuclease 1/FEN-1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displa...
TMPH-00043	Fanconi-associated nuclease 1 Protein, Ailuropoda melanoleuca, Recombinant (His & Myc)	Ailuropoda melanoleuca	E. coli
	Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficien...
TMPH-02649	FAN1 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficien...
TMPY-01480	LTC4S Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Leukotriene C4 synthase, also known as LTC4 synthase, Leukotriene-C(4) synthase, and LTC4S, is a multi-pass membrane protein that belongs to the MAPEG family. LTC4S is detected in the lung, platelets, and the myelogenous...