mTOR

The mammalian target of rapamycin (mTOR), sometimes also referred to as the mechanistic target of rapamycin and FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene. mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases.mTOR links with other proteins and serves as a core component of two distinct protein complexes, mTOR complex 1 and mTOR complex 2, which regulate different cellular processes. In particular, as a core component of both complexes, mTOR functions as a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. As a core component of mTORC2, mTOR also functions as a tyrosine protein kinase that promotes the activation of insulin receptors and insulin-like growth factor 1 receptors. mTORC2 has also been implicated in the control and maintenance of the actin cytoskeleton.

Cat. No.	Product name	CAS No.	Purity
TN3218	7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one	100667-52-5	98%
TN3218	7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may...
TN2118	Lup-20(29)-en-28-oic acid	848784-85-0	98%
TN2118	Lup-20(29)-en-28-oic acid exhibits anticancer activities in various cancer types, it Inhibits autophagic flux and synergistically enhances the anticancer activit...
T28285	P-2281	1112994-35-0	99.95%
T28285	P-2281 is an mTOR inhibitor with anticancer and anti-inflammatory properties.P-2281 inhibits dextran sulfate sodium (DSS)-induced colitis by suppressing T-cell f...
T3692	GNE-477	1032754-81-6	99.95%
T3692	GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.
T2P2806	Hederacolchiside A1	106577-39-3	99.92%
T2P2806	Hederacolchiside A1 (Raddeanoside R13) shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the paras...
T2265	Bimiralisib	1225037-39-7	99.88%
T2265	Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity. PI3K-IN-2 inhibits the...
TN1140	Onjisaponin B	35906-36-6	99.88%
TN1140	Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-sy...
T2144	Tacrolimus	104987-11-3	99.87%
T2144	Tacrolimus (Fujimycin) can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits the activity of the calcium/calmodulin-dependent protein phosp...
T2619	CH5132799	1007207-67-1	99.87%
T2619	CH5132799 has been used in trials studying the treatment of Solid Tumors.
T14552	Dactolisib Tosylate	1028385-32-1	99.85%
T14552	Dactolisib Tosylate (BEZ235 Tosylate) is a dual kinase inhibitor that targets PI3K and mTOR. dactolisib Tosylate exhibits IC50 values of 4, 75, 7, and 5 nM for P...
T2616	PIK-93	593960-11-3	99.83%
T2616	PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
T2685	KU-55933	587871-26-9	99.80%
T2685	KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.
T16567	PQR530	1927857-61-1	99.78%
T16567	PQR530 is a highly potent dual pan-PI3K/mTORC1/2 inhibitor. PQR530 inhibited protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphor...
T35343	MTI-31	1567915-38-1	99.76%
T35343	MTI-31 (LXI-15029) is a potent, orally active and highly selective inhibitor of mTORC1 and mTORC2. MTI-31 is selective for mTOR (Kd: 0.20 nM) versus PIK3CA, PIK3...
T16741	Rheb inhibitor NR1	2216763-38-9	99.72%
T16741	Rheb inhibitor NR1 is a Rheb inhibitor and selective mTORC1 inhibitor.Rheb inhibitor NR1 inhibits the phosphorylation of T389pS6K1 and promotes the phosphorylati...
T60055	Chromeceptin	331859-86-0	99.72%
T60055	Chromeceptin is an inhibitor of the IGF signaling pathway, decreases the numbers of tumorsphere, and inhibits the AKT/mTOR pathway.
T2235	Dactolisib	915019-65-7	99.71%
T2235	Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).
T11381	Pictilisib dimethanesulfonate	957054-33-0	99.69%
T11381	Pictilisib dimethanesulfonate (GDC-0941 2 MeSO3H salt) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p1...
T2145	Temsirolimus	162635-04-3	99.64%
T2145	Temsirolimus (CCI-779) is a specific mTOR inhibitor ( IC50: 1.76 μM), used in the treatment of advanced renal cell cancer.
T6730	WAY-600	1062159-35-6	99.63%
T6730	WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308); sel...