Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.

Cat. No.	Product name	CAS No.	Purity
T2220	2-Methoxyestradiol	362-07-2	99.95%
T2220	2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by red...
T1569	Tigecycline	220620-09-7	99.94%
T1569	Tigecycline (GAR-936) is a broad-spectrum glycylcycline antibiotic derived from tetracycline. Tigecycline binds to the 30S ribosomal subunit, thereby interfering...
T2355	CFTR(inh)-172	307510-92-5	99.94%
T2355	CFTR(inh)-172 (CFTR Inhibitor-172) is a voltage-independent, selective CFTR inhibitor.
T1535	Sodium 4-phenylbutyrate	1716-12-7	99.94%
T1535	Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increas...
T2492	Perifosine	157716-52-4	99.94%
T2492	Perifosine (KRX-0401) is an oral-active, alkyl-phosphocholine Akt inhibitor with potential antineoplastic activity.
T17209	UVI 3003	847239-17-2	99.94%
T17209	UVI 3003 is a highly selective antagonist of the retinoid X receptor. UVI 3003 inhibits Xenopus and human RXRα in Cos7 cells (IC50s: 0.22 and 0.24 μM, respective...
T6151	GW 501516	317318-70-0	99.94%
T6151	GW 501516 (Endurobol) is a effective and highly specifc PPARβ/δ agonist (EC50: 1 nM), with 1000-fold selectivity over hPPARα/γ.
T1969	DBEQ	177355-84-9	99.94%
T1969	DBEQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor.
T4645	TA-01	1784751-18-3	99.94%
T4645	TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.
T2233	GW 4064	278779-30-9	99.94%
T2233	GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).
T1105	Penfluridol	26864-56-2	99.94%
T1105	Penfluridol (TLP-607) is a highly potent antipsychotic.
T4S2126	Ginkgetin	481-46-9	99.94%
T4S2126	1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against...
T6167	SU9516	377090-84-1	99.94%
T6167	SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also has inhibitory effects on CDK1 and CDK4, with IC50s of 40 nM and 200 nM, respectively.
T0010	6-Mercaptopurine	50-44-2	99.94%
T0010	6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting puri...
T2829	Isoalantolactone	470-17-7	99.94%
T2829	Isoalantolactone (Isohelenin), isolated from Inula spp., can inhibit the growth of several types of Y cells.
T3843	Pinosylvin	22139-77-1	99.93%
T3843	Pinosylvin (5-Styrylresorcinol) induces autophagy via AMPK activation. Pinosylvin is likely to act as a pro-angiogenic factor.
T1583	Vorinostat	149647-78-9	99.93%
T1583	Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1/2/3/6/7/11. Vorinostat has antitumor activity...
T0132	Etoposide	33419-42-0	99.93%
T0132	Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM). Etoposide ha...
T0164	Oxaliplatin	61825-94-3	99.93%
T0164	Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis. Oxaliplatin causes DNA cross-linking damage, preventing DNA replication and transcr...
T2202	Lithocholic acid	434-13-9	99.93%
T2202	Lithocholic acid (3α-Hydroxy-5β-cholanic acid) is a bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It a...