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DSP-0390
DSP0390, DSP 0390
T2019322376765-57-8
DSP-0390 is an oral inhibitor of emopamil binding protein (EBP). It effectively suppresses the EBP enzyme, which is involved in a critical late-stage step of cholesterol biosynthesis. By inhibiting the synthesis of new cholesterol, DSP-0390 selectively induces cytotoxicity in rapidly proliferating GBM cells. In human GBM xenograft models, DSP-0390 has demonstrated significant antitumor activity.
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