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Cat No. | Product Name | Synonyms | Targets |
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T6721 | Vinblastine | Microtubule Associated , AChR | |
Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to treat certain kinds of cancer. | |||
T18330 | MC-Val-Cit-PAB-vinblastine | Others | |
MC-Val-Cit-PAB-vinblastine is a drug-linker conjugate for ADC with potent antitumor activity by using vinblastine (an microtubule protein inhibitor), linked via the ADC linker MC-Val-Cit-PAB. | |||
T29434 | 4-Desacetylvinblastine hydrazide | DAVLBH,Deacetylvinblastine hydrazide,Desacetylvinblastine hydrazide | |
Deacetylvinblastine hydrazide, a cytotoxic vinca alkaloid often conjugated with folic acid to produce EC145, a novel folate-receptor targeted agent. | |||
T10772 | Cevipabulin | TTI-237 | Microtubule Associated |
Cevipabulin (TTI-237) is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line). | |||
T21317 | Avanbulin | BAL27862,BAL-27862,BAL 27862 | |
Avanbulin is a potent inhibitor of tubulin polymerization with antitumor activity. It elicits a unique microtubule (MT) phenotype, distinct from colchicine, paclitaxel, and vinblastine has broad in vitro anti-proliferati... | |||
T10772L | Cevipabulin fumarate | TTI-237 fumarate | Others |
Cevipabulin (TTI-237) fumarate is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line). | |||
T13672 | EC0489 | Others | |
EC0489, Small molecule-drug conjugate (SMDC) ,a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor. | |||
T36856 | UA 62784 | ||
Inhibitor of microtubule polymerization in vitro. Interacts with tubulin dimers and promotes the accumulation of mammalian cells in apoptosis. Potentiates antiproliferative effects of vinblastine in H2B-GFP HeLa cells. O... | |||
T17727 | CCK2R Ligand-Linker Conjugates 1 | Others | |
CCK2R Ligand-Linker Conjugate 1 is a hydrophilic peptide linker that conjugates to the cytotoxic antimicrotubule agents Desacetyl Vinblastine Hydrazide (DAVBH) and Tubulysin B Hydrazide (TubBH) as ligand-linker conjugate... | |||
T26413 | A 30312 | A-30312,A30312 | |
A 30312 is a fused indole, which overcomes multidrug resistance in P388/Adr cells in vitro. It potentiates the cytotoxicity of the antitumor drugs Adriamycin, vincristine and vinblastine in multidrug-resistant cells with... | |||
T38011 | C2 Adamantanyl Globotriaosylceramide (d18:1/2:0) | ||
C2 Adamantanyl globotriaosylceramide (AdaGb3) is a bioactive sphingolipid and water-soluble form of globotriaosylceramide that contains an adamantanyl group in place of the fatty acyl chain. It inhibits Vero toxin bindin... | |||
T25025 | ALB-109564 dihydrochloride | ||
ALB-109564 dihydrochloride is a semi-synthetic derivative of the vinka alkaloid vinblastine with potential antineoplastic activity, a microtubule protein inhibitor and antineoplastic compound. It binds to tubulin monom... | |||
T35616 | Migrastatin | ||
Migrastatin is a bacterial metabolite that has been found inStreptomyceswith antimuscarinic and anticancer activities.1,2It binds to M1-5muscarinic acetylcholine receptors (Kis = >200, 200, 31, 43, and >200 μM, respectiv... | |||
T71252 | PC-046 | ||
PC-046 is a potent tubulin-binding agent, which was originally identified for development based on selective activity in deleted in pancreas cancer locus 4 (DPC4/SMAD4) deficient tumors. PC-046 has growth inhibitory acti... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1668 | Vinblastine sulfate | NSC49842,Vincaleukoblastine sulfate salt | Microtubule Associated , AChR , Autophagy |
Vinblastine sulfate (Vincaleukoblastine sulfate salt) can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM). | |||
T22455 | Vindesine sulfate | DVA,Desacetylvinblastine amide,DAVA,Desacetyl Vinblastine amide,VDS | Others |
Vindesine sulfate (Desacetyl Vinblastine amide) is a vinca alkaloid which is a synthetic derivative of vinblastine, binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule... | |||
T12540 | Pristinamycin IA | Mikamycin IA,Mikamycin B | Others , Antibiotic , P-gp |
Pristinamycin IA (Mikamycin B) is a substrate for the P-glycoprotein and a cyclo-peptidic macrolactone antibiotic. | |||
T3022 | Anhydrovinblastine | 3',4'-Anhydrovinblastine | Others |
3', 4'-Anhydrovinblastine (3',4'-Anhydrovinblastine) is an antineoplastic agent. | |||
TN4695 | Odorine | Others | |
Odorine has potent anti-carcinogenic effect by inhibiting both the initiation and promotion stages of two-stage skin carcinogenesis. It was found to inhibit the growth of the vinblastine-resistant KB cells by enhancing t... | |||
TN5153 | Torilin | MMP , ERK , IκB/IKK , p38 MAPK , NF-κB , Tyrosinase , Reductase , DNA/RNA Synthesis , JNK | |
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic acid (IC50 = 160.3 +/- 24.62 microM) but is weaker than fi... |