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Search Results for " mds "

Targets

10

Compounds

13

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T4570 Pipobroman Vercyte,A-8103,Amedel Others , DNA Alkylator/Crosslinker
Pipobroman (Vercyte) is an anti-cancer drug that probably acts as an alkylating agent. Pipobroman has well documented clinical activity in polycythemia vera (PV) and essential thrombocythemia (ET). Pipobroman allows, wit...
T5097 Ezatiostat TER199(free base),TLK199 Apoptosis , Glutathione Peroxidase , GST
Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.
TQ0059 Ilorasertib ABT-348 VEGFR , FLT , c-RET , PDGFR , Aurora Kinase
Ilorasertib (ABT-348) (ABT-348) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora A/Aurora B/Aurora C (IC50s: 120 nM/7 nM/1 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: ...
T22776 Ezatiostat hydrochloride TLK199 HCl,TER199 Glutathione Peroxidase
Ezatiostat hydrochloride (TLK199 HCl) is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatment of cytopenias. In addition, Ezatiostat hydr...
T76975 Tomaralimab OPN-305 TLR
Tomaralimab (OPN-305) is a humanized IgG4 monoclonal antibody targeting TLR2. Tomarlimab is used to study myelodysplastic syndromes (MDS).
T6332 Pevonedistat MLN4924 E1/E2/E3 Enzyme , NEDD8
Pevonedistat (MLN4924) is a potent and selective NEDD8 activating enzyme (NAE) inhibitor (IC50=4.7 nM). Pevonedistat can be used for the treatment of myelodysplastic syndromes (MDS) and also has antitumor activity.
T64133L Laniquidar TFA Laniquidar TFA(197509-46-9 Free base),R101933 P-gp
Laniquidar TFA (R101933) is a novel orally available non-competitive P-glycoprotein (P-gp) inhibitor with an IC50 value of 0.51 μM.Laniquidar has limited bioavailability and can be used to modulate the multidrug resistan...
T16384 Olutasidenib FT-2102 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
Olutasidenib (FT-2102) is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Olutasidenib is a highly effective, brain penetrant, and selective inhibitor of the mutant Iso...
T76911 Asunercept
Asunercept (APG101; CAN008), a soluble CD95-Fc fusion protein, selectively targets and binds to CD95L, effectively disrupting CD95/CD95L signaling. It is utilized in research for treating glioblastoma multiforme (GBM), m...
T64133 Laniquidar
Laniquidar (R101933) is a third generation non-competitive inhibitor of P-glycoprotein (P-gp) (IC50: 0.51 μM) with limited oral bioavailability. It can also be used to modulate multidrug resistance transporters.

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-01267 14-3-3 epsilon Protein, Human, Recombinant (GST) Human E. coli
YWHAE, also known as 14-3-3 epsilon, mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 epsilon / YWHAE is a member of the 14-3-3 proteins family. 14-3-3 proteins are a group of highly co...
TMPY-01274 14-3-3 epsilon Protein, Human, Recombinant Human E. coli
YWHAE, also known as 14-3-3 epsilon, mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 epsilon / YWHAE is a member of the 14-3-3 proteins family. 14-3-3 proteins are a group of highly co...
TMPY-03507 PPC-DC Protein, Human, Recombinant (E. coli, His) Human E. coli
PPC-DC, also known as PPCDC, belongs to the HFCD (homo oligomeric flavin containing Cys decarboxylase) superfamily which takes a part in the biosynthesis of coenzyme A (CoA) from pantothenate (Vitamin B). Biosynthesis of...
TMPY-03227 CISD1 Protein, Human, Recombinant (His) Human E. coli
Mitochondrial dysfunction is thought to play a significant role in neurodegeneration observed in Parkinson's disease (PD), the loss of mitoNEET (CISD1), an iron-sulfur containing protein that regulates mitochondrial bioe...
TMPY-01410 IL-3R alpha/CD123 Protein, Human, Recombinant (His) Human HEK293
Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 5 subf...
TMPY-05418 IL-3R alpha/CD123 Protein, Human, Recombinant (hFc) Human HEK293
Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 5 subf...
TMPY-06744 IL-3R alpha/CD123 Protein, Human, Recombinant (hFc & Avi), Biotinylated Human HEK293
Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 5 subf...
TMPY-00592 IL-3R alpha/CD123 Protein, Mouse, Recombinant (His) Mouse HEK293
Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 5 subf...
TMPY-04034 IL-3R alpha/CD123 Protein, Canine, Recombinant (His) Canine HEK293
Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 5 subf...
TMPY-06793 IL-3R alpha/CD123 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 5 subf...
TMPY-00076 IL-3R alpha/CD123 Protein, Mouse, Recombinant (hFc) Mouse HEK293
Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 5 subf...
TMPY-06715 IL-3R alpha/CD123 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 5 subf...
TMPY-02043 PARK7/DJ-1 Protein, Human, Recombinant (His) Human E. coli
Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress....
Cat No. Product Name
L8400 Hematonosis Compound Library

524 compounds
A unique collection of 524 compounds related to hematologic diseases for high throughput screening (HTS) and high content screening (HCS);
TargetMol