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Search Results for " hras "

6

Compounds

5

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T32104 Hras-1Y i-motif Probe-1
Hras-1Y i-motif Probe-1 is a probe of the hras-1Y i-motif which selectively and directly interacts with it.
T8970 ML162 Ferroptosis , GPX , Glutathione Peroxidase
ML162 is an inhibitor of GPX4 that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively)
T81263 RMC-7977 Ras
RMC-7977 is a reversible, tri-complex RAS inhibitor that demonstrates broad-spectrum activity against mutant and wild-type (WT) KRAS, NRAS, and HRAS variants. This compound has been shown to induce tumor regressions and ...
T28733 SCH-53870
SCH-53870 inhibits p21-hRas nucleotide exchange in vitro.
T64000 MRTX-EX185
MRTX-EX185 is an effective inhibitor of GDP-loaded KRAS and KRAS (G12D) with an IC50=90 nM for KRAS (G12D). MRTX-EX185 is also capable of binding GDP-loaded HRAS.
T36641 RAS inhibitor Abd-7
RAS inhibitor Abd-7 is a powerful compound (Kd=51 nM) that binds to RAS and inhibits the protein-protein interaction (PPI) between RAS and its effectors. By interacting with RAS within cells, RAS inhibitor Abd-7 hinders ...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-02220 HRAS Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
HRas, also known as HRAS, belongs to the small GTPase superfamily, Ras family, and is widely expressed. It functions in signal transduction pathways. HRas can bind GTP and GDP, and they have intrinsic GTPase activity. It...
TMPJ-01010 PLA2G16 Protein, Human, Recombinant (His) Human E. coli
Group XVI Phospholipase A1/A2 (PLA2G16) belongs to the H-rev 107 family. PLA2G16 is expressed in a number of human tumors including ovarian carcinomas, lung carcinomas. PLA2G16 is involved in the regulation of differenti...
TMPJ-00702 APT-1 Protein, Human, Recombinant (His) Human E. coli
Acyl-Protein Thioesterase 1 (APT-1) is lysophospholipase that belongs to the AB hydrolase 2 family. Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. APT-1...
TMPY-03487 NRAS Protein, Human, Recombinant (His) Human E. coli
NRAS was discovered by researchers at the Institute of Cancer Research, funded by the Cancer Research Campaign (now Cancer Research UK). NRAS gene is a member of the Ras gene family. It is mapped on chromosome 1, and it ...
TMPY-02132 LYPLA2 Protein, Human, Recombinant (His) Human E. coli
Lysophospholipase II (LYPLA2, LPL-II, or LysoPLA II), also known as Acyl-protein thioesterase 2 (APT-2), belongs to the AB hydrolase 2 family. This enzyme has lysophospholipase activity and may hydrolyze fatty acids from...
TargetMol