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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6058 | LY2886721 | Beta-Secretase , BACE | |
LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease. | |||
T8719 | SC99 | Apoptosis , JAK , STAT | |
SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes.SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activiti... | |||
T23602 | ABC99 | ABC 99,ABC-99 | Wnt/beta-catenin |
ABC99 is a selective irreversible inhibitor of the wnt-deacylating enzyme. ABC99 inhibited NOTUM (IC50: 13 nM). It also showed excellent selectivity across the serine hydrolase family. | |||
T12071 | MKC9989 | IRE1 | |
MKC9989 is an inhibitor of Hydroxy aryl aldehydes (HAA). MKC9989 also inhibits IRE1α with an IC50 of 0.23 to 44 μM. | |||
T29064 | UNC9975 | UNC-9975 | |
UNC9975 is an analog of aripiprazole and a β-arrestin-biased D2R agonist. | |||
T29065 | UNC9994 | UNC-9994,UNC 9994 | |
UNC9994 is a β-arrestin-biased dopamine D₂ receptor agonist (β-arrestin EC50 = 50 nM; Emax = 97%) with robust in vivo antipsychotic drug-like activities. | |||
T29066 | UNC9995 | UNC-9995,UNC 9995 | |
UNC9995 is a β-Arrestin-Biased Dopamine D2 Receptor agonist (β-Arrestin, EC50 = 120 nM; Emax = 88%). | |||
T62853 | UNC9994 hydrochloride | ||
UNC9994 hydrochloride is a functionally selective, β-arrestin-biased dopamine D2 receptor (D2R) agonist (Ki: 79 nM) that selectively activates β- arresttin recruitment and signal transduction. UNC9994 hydrochloride is a ... | |||
T116837 | TLC9995-0188 | ||
Tyrosine-protein kinase ABL, IC50: 1500 nM | |||
T6870 | L-685458 | L-685,458 | Apoptosis , Gamma-secretase |
L-685458 (L-685,458) is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM. |