Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.

Cat. No.	Product name	CAS No.	Purity
T3122	Fangchinoline	436-77-1	99.98%
T3122	Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.
T1703	SN-38	86639-52-3	99.97%
T1703	SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM). SN-38 h...
T0380	Bicalutamide	90357-06-5	99.97%
T0380	Bicalutamide (ICI-176334), a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the ...
T0847	Chenodeoxycholic acid	474-25-9	99.97%
T0847	Chenodeoxycholic acid (CDCA) is a bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorpti...
T1149	Fenofibrate	49562-28-9	99.97%
T1149	Fenofibrate (Lipanthyl) is a peroxisome proliferator receptor alpha agonist. Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyp...
T1789	Obeticholic Acid	459789-99-2	99.97%
T1789	Obeticholic Acid (6-ECDCA) is a Farnesoid X Receptor Agonist. The mechanism of action of obeticholic acid is as a Farnesoid X Receptor Agonist.
T3155	SMER28	307538-42-7	99.97%
T3155	SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells via an mTOR-independent mechanism and p...
T0747	Sulfathiazole	72-14-0	99.97%
T0747	Sulfathiazole (2-Sulfanilamidothiazole), an organosulfur compound, has been served as a short-acting sulfa medicine.
T3045	Salubrinal	405060-95-9	99.97%
T3045	Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).
T2187	Orthanilamide	3306-62-5	99.96%
T2187	Orthanilamide (Orthanilamide) is a molecule containing the sulfonamide functional group attached to an aniline.
T2509	Tozasertib	639089-54-6	99.96%
T2509	Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C). It shows selectivity against more than 190 different k...
T15806	LY2562175	1103500-20-4	99.96%
T15806	LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).
T6671	Sirtinol	410536-97-9	99.96%
T6671	Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).
T1330	Acitretin	55079-83-9	99.95%
T1330	Acitretin (Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.
T0920	Ambroxol	18683-91-5	99.95%
T0920	Ambroxol (NA-872) is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of...
T6037	E-64	66701-25-5	99.95%
T6037	E-64 (Proteinase inhibitor E 64) is an irreversible and specific cysteine protease inhibitor. The IC50 of E-64 for papain is 9 nM.
T6994	SR12813	126411-39-0	99.95%
T6994	SR12813 (GW 485801) is a pregnane X receptor (PXR) agonist.
T0687	Simvastatin	79902-63-9	99.95%
T0687	Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity. Simvastatin has hypolipidemic activity, inhibits hepatic production of cho...
T6087	AZD 6482	1173900-33-8	99.95%
T6087	AZD 6482 (AZD6482) is a potent and selective p110β inhibitor with IC50 of 0.69 nM and a PI3Kβ inhibitor with IC50 of 10 nM.
T0191	Linagliptin	668270-12-0	99.95%
T0191	Linagliptin (BI 1356) is a potent, orally bioavailable dihydropurinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.