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Search Results for " prolyl-trna "

Targets

6

Compounds

2

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T8785 HALOFUGINONE LACTATE DNA/RNA Synthesis , TGF-beta/Smad
HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner ...
T69800 T-3861174
T-3861174 is a prolyl tRNA synthetase (PRS) inhibitor, exhibiting significant in vitro anti-tumor activity with GCN2-ATF4 pathway activation.
T69741 DWN-12088 HCl
DWN-12088 HCl is the salt form of DWN-12088 Free Base, an orally administered small molecule prolyl-tRNA synthetase (PRS) inhibitor
T39739 Bersiporocin
Bersiporocin, a prolyl-tRNA synthetase inhibitor, demonstrates potent activity with an IC50 of ≤100 nM against phosphoribosylpyrophosphate synthetase (PRS). This compound proves valuable for antifibrotic research.
T72303 Antibacterial agent 124
Antibacterial agent 124 is a potent inhibitor of bacterial prolyl-tRNA synthetase (ProRS), specifically targeting Staphylococcus aureus ProRS (Sa ProRS) with an inhibitory concentration (IC50) of 0.18 μM.
T79449 Antileishmanial agent-19 Parasite
Compound F27 (Antileishmanial agent-19) is an antileishmanial compound effective against L. donovani promastigotes, demonstrating an IC50 of 3.39 μM. It functions by inhibiting the Leishmania prolyl-tRNA synthetase and d...
Cat No. Product Name Synonyms Targets
T6856 Halofuginone Tempostatin,empostatin,RU-19110 Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal.
T3524 Halofuginone hydrobromide Tempostatin,RU-19110 (hydrobromide),Stenorol Others , Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-03976 EEF1E1 Protein, Human, Recombinant (His) Human E. coli
EEF1E1, also known as AIMP3 and p18, is a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, EEF1E1 is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex...
TargetMol