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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2437 | O4I2 | O-4I2,O4I2 | OCT |
O4I2 is an effective Oct3/4 inducer in various human cell lines including human fibroblasts. | |||
T3221 | Oct3/4-inducer-1 | 2-(4-(4-methoxybenzyloxy)phenyl)acetonitrile | Others , OCT |
Oct3/4-inducer-1 (2-(4-(4-methoxybenzyloxy)phenyl)acetonitrile) is an OCT3/4 inducer that promotes the expression and stabilization of OCT3/4 and enhances its transcriptional activity in a variety of human cells. | |||
T3031 | A 83-01 | ALK5 Inhibitor IV,A8301 | ALK , TGF-beta/Smad |
A 83-01 (ALK5 Inhibitor IV) is an inhibitor of the TGF-β type I receptors ALK5, ALK4, and ALK7 (IC50=12/45/7.5 nM). A 83-01 promotes the reprogramming of mouse fibroblasts into iPSCs. A 83-01 can be used in organoid cult... | |||
T3636 | (E)-SIS3 | SIS3,SIS3 HCl | TGF-beta/Smad |
(E)-SIS3 (SIS3), a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signaling. It also inhibits TGF-β1-induced myofibroblas... | |||
T2019 | OAC2 | OCT | |
OAC2 is an Oct4 activator which activates expression through the Oct4 gene promoter; enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibrobl... | |||
T35670 | Miro1 Reducer | ||
Promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC50 = 7.8 μM). Exhibits no significant effect on related outer mitochon... | |||
T35541 | Lipoxygenin | ||
Lipoxygenin is an inhibitor of 5-lipoxygenase (5-LO) with an IC50value of 5 μM for inhibition of 5-LO product synthesis in isolated human granulocytes stimulated with the cation ionophore A23187 .1It inhibits hedgehog-de... |