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Search Results for " ewing "

Targets

9

Compounds

Cat No. Product Name Synonyms Targets
T13166 TK216 Others , DNA/RNA Synthesis
TK216 is a potent inhibitor of E26 transformation-specific (ETS) with anticancer activity.
T4527 Seclidemstat SP-2577 Histone Demethylase
Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM.
T2465 PF-562271 PF562271,PF 562271 FAK , PYK2 , CDK
PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).
T21768 PF-562271 hydrochloride PF-562271 HCl FAK , PYK2 , CDK
PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other pr...
T83064 Anti-hepatic fibrosis agent 2
Compound 6k, also known as Anti-hepatic fibrosis agent 2, is an orally active inhibitor of the COL1A1 enzyme and exerts anti-fibrogenic effects by targeting the Ewing sarcoma breakpoint region 1 (EWSR1)[1].
T76759 Robatumumab
Robatumumab (Sch 717454), an anti-human insulin-like growth factor receptor-1 (IGF-1R) antibody, exhibits anti-tumor and anti-proliferative effects on cancer cells. It is applicable in research concerning osteosarcoma an...
T78982 BK60106 Apoptosis
BK60106, a CD99 inhibitor, selectively targets and binds to the extracellular domain of CD99, effectively inducing apoptosis in Ewing sarcoma (ES) cells with minimal associated DNA damage [1].
T39439 Seclidemstat mesylate SP-2577 mesylate
Seclidemstat mesylate (SP-2577) is a highly effective and reversible inhibitor of KDM1A (LSD1), with a Ki of 31 nM and an IC 50 of 13 nM. It demonstrates significant potential in promoting antitumor immunity in switch/su...
T36253 DTAGV-1
Degrader targeting mutant FKBP12F36V fusion proteins. Comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a von Hippel-Lindau (VHL)-binding ligand. Induces potent and selective degradation of ...
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