ack1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3709	XMD8-87	ACK1-B19	Tyrosinase , PPAR
	XMD8-87 (ACK1-B19) is a TNK2 inhibitor with activity in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation mutations found in solid tumor types.		Tyrosinase , PPAR
T5092	AIM-100	AIM100	ACK
	AIM-100 is a Ack1 inhibitor (IC50: 24 nM).		ACK
T3196	GNF-7	GNF7	Bcr-Abl , ACK , AChR
	GNF-7 is Bcr-Abl WT and Bcr-Abl T315I inhibitor with IC50 of 133 nM and 61 nM, respectively.		Bcr-Abl , ACK , AChR
T2641	KRCA-0008	KRCA 0008,KRCA0008	ACK , ALK
	KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.		ACK , ALK
TP1971	Pseudo RACK1
	Activator of protein kinase C; attached to cell permeabilization Antennapedia domain vector peptide. Consists of peptide derived from the C2 domain of PKC β linked by a disulfide bridge to the Antennapedia domain vector ...
T68740	NVP-TAC544
	NVP-TAC544 is a novel focal adhesion kinase (FAK) inhibitor, potently blocking kinase activity of FAK along with Aurora A, activated Cdc42-associated kinase 1 (ACK1), Met, insulin receptor (IR), TrkA, and IGF-1R.
T2382	Vemurafenib	RO5185426,RG7204,PLX4032	Raf , MAPK , ACK , Src , Autophagy
	Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and potently. Vemurafenib exhibits antitumor activity and is used for the treatment of BRAF V600E mutation-positive...		Raf , MAPK , ACK , Src , Autophagy
T13564L2	AZ7550 trimesylate salt	AZ7550 Mesylate,AZ7550 trimesylate salt (1421373-99-0 free base)	MLK
	AZ7550 trimesylate salt (AZ7550 Mesylate) is the active metabolite of ositinib, AZ7550 trimesylate salt inhibits IGF1R activity and can be used in the study of non-small cell lung cancer.		MLK
T13564	AZ7550		MLK , FAK , EGFR , FLT , Tyrosine Kinases , PYK2 , MNK , IGF-1R , ACK , BTK , ALK , Drug Metabolite
	AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T13564L	AZ7550 hydrochloride	AZ7550 hydrochloride (1421373-99-0 free base)	EGFR , IGF-1R
	AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).		EGFR , IGF-1R

Compounds

XMD8-87

T3709

Synonym: ACK1-B19

Target: Tyrosinase, PPAR

Target: Bcr-Abl, ACK, AChR

KRCA-0008

T2641

Synonym: KRCA 0008,KRCA0008

Synonym: RO5185426,RG7204,PLX4032

Target: Raf, MAPK, ACK, Src, Autophagy

AZ7550 trimesylate salt

T13564L2

Synonym: AZ7550 Mesylate,AZ7550 trimesylate salt (1421373-99-0 free base)

Target: MLK, FAK, EGFR, FLT, Tyrosine Kinases, PYK2, MNK, IGF-1R, ACK, BTK, ALK, Drug Metabolite

AZ7550 hydrochloride

T13564L

Synonym: AZ7550 hydrochloride (1421373-99-0 free base)

Target: EGFR, IGF-1R

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-04484	ACK1 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	ACK1 (also known as ACK, TNK2, or activated Cdc42 kinase) is a structurally unique non-receptor tyrosine kinase that is expressed in diverse cell types. This downstream effector of CDC42 mediates CDC42-dependent cell mig...
TMPY-02761	Rack1 Protein, Human, Recombinant (His & MBP)	Human	E. coli
	The scaffolding protein, Rack1, is a seven-WD-domain-containing protein that has been implicated in binding to integrin beta subunit cytoplasmic domains and to members of two kinase families (src and protein kinase C, PK...
TMPH-01086	CSPG4 Protein, Human, Recombinant (His & Myc)	Human	HEK293
	Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon rege...